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COVID-19 in adult acute myeloid leukemia patients: a long-term followup study from the European Hematology Association survey (EPICOVIDEHA)
- Source :
- Haematologica, 108(1), 22-33. FERRATA STORTI FOUNDATION, Scientia, HAEMATOLOGICA
- Publication Year :
- 2022
-
Abstract
- COVID-19; Acute myeloid leukemia; Survey COVID-19; Leucemia mieloide aguda; Encuesta COVID-19; Leucèmia mieloide aguda; Enquesta Patients with acute myeloid leukemia (AML) are at high risk of dying from coronavirus disease 2019 (COVID-19). The optimal management of AML patients with COVID-19 has not been established. Our multicenter study included 388 adult AML patients diagnosed with COVID-19 between February 2020 and October 2021. The vast majority were receiving or had received AML treatment in the preceding 3 months. COVID-19 was severe in 41.2% and critical in 21.1% of cases. The chemotherapeutic schedule was modified in 174 patients (44.8%), delayed in 68 and permanently discontinued in 106. After a median follow-up of 325 days, 180 patients (46.4%) had died; death was attributed to COVID-19 (43.3%), AML (26.1%) or to a combination of both (26.7%), whereas in 3.9% of cases the reason was unknown. Active disease, older age, and treatment discontinuation were associated with death, whereas AML treatment delay was protective. Seventy-nine patients had a simultaneous AML and COVID-19 diagnosis, with better survival when AML treatment could be delayed (80%; P
- Subjects :
- Settore MED/15 - MALATTIE DEL SANGUE
Leucèmia mieloide aguda
neoplasias::neoplasias por tipo histológico::leucemia::leucemia mieloide::leucemia mieloide aguda::leucemia monocítica aguda [ENFERMEDADES]
Medicine and Health Sciences
virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES]
Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES]
Hematology
Neoplasms::Neoplasms by Histologic Type::Leukemia::Leukemia, Myeloid::Leukemia, Myeloid, Acute::Leukemia, Monocytic, Acute [DISEASES]
03.02. Klinikai orvostan
Settore MED/15
Infection
COVID-19 (Malaltia)
AML, COVID19
Subjects
Details
- Language :
- English
- ISSN :
- 03906078 and 15928721
- Database :
- OpenAIRE
- Journal :
- Haematologica, 108(1), 22-33. FERRATA STORTI FOUNDATION, Scientia, HAEMATOLOGICA
- Accession number :
- edsair.doi.dedup.....c6de49464af12c04f670f32ee147b18b