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Prevalence of murine astrovirus in laboratory animal facilities in Japan
- Source :
- The Journal of Veterinary Medical Science
- Publication Year :
- 2020
- Publisher :
- The Japanese Society of Veterinary Science, 2020.
-
Abstract
- To investigate the prevalence of murine astrovirus (MuAstV) in mice in laboratory animal facilities in Japan, a polymerase chain reaction (PCR) test targeting the RNA-dependent RNA polymerase (RdRP) gene was performed on the cecum contents of 1,212 mice (1,183 immunocompetent mice and 29 immunodeficient mice) from 226 facilities. The results showed that 118 (52.2%) of the 226 facilities were positive for MuAstV. Out of the 1,212 mice, 424 (35.0%) were positive. No gross lesions were observed in any of the mice examined. A phylogenetic analysis for 15 selected strains revealed that 13 strains formed one cluster, while two were genetically distant from that cluster. These results suggest that multiple strains are prevalent in laboratory mice in Japan.
- Subjects :
- 040301 veterinary sciences
prevalence
Biology
Disease cluster
Polymerase Chain Reaction
law.invention
0403 veterinary science
Rodent Diseases
03 medical and health sciences
Cecum
chemistry.chemical_compound
Immunocompromised Host
Mice
Japan
law
Laboratory Animal Science
RNA polymerase
Animals, Laboratory
Astroviridae Infections
medicine
Animals
Gene
Polymerase chain reaction
Phylogeny
030304 developmental biology
0303 health sciences
laboratory mice
General Veterinary
Phylogenetic tree
04 agricultural and veterinary sciences
Note
Virology
murine astrovirus
medicine.anatomical_structure
chemistry
Astroviridae
Murine astrovirus
Subjects
Details
- Language :
- English
- ISSN :
- 13477439 and 09167250
- Volume :
- 82
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- The Journal of Veterinary Medical Science
- Accession number :
- edsair.doi.dedup.....c6e38c2df419945d8a662664e6044f74