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Use of Plasmapheresis and Immunosuppressants to Treat Diffuse Alveolar Hemorrhage in a Patient with Granulomatosis with Polyangiitis
- Source :
- Medicina, Medicina, Vol 55, Iss 7, p 378 (2019)
- Publication Year :
- 2019
- Publisher :
- MDPI AG, 2019.
-
Abstract
- Granulomatosis with polyangiitis (GPA) is a systemic granulomatous inflammatory disease characterized by small-to-medium vessel vasculitis due to Central Anti-Neutrophil Cytoplasmic Antibody (C-ANCA). GPA commonly involves the lungs and the kidneys. Among the pulmonary manifestations, diffuse alveolar hemorrhage (DHA) is a rare presentation of GPA that can present with hemoptysis leading to acute onset of anemia and hemodynamic instability. An active diagnostic workup including serologic titer of C-ANCA, imaging, intensive care, and aggressive immunosuppression is the key to DAH management. We report a case of DAH secondary to GPA that presented with hemoptysis leading to severe anemia, initially resuscitated symptomatically and started on plasmapheresis with pulse steroids and cyclophosphamide. Timely diagnosis and management led to a remarkable recovery of the pulmonary symptoms and imaging findings of DAH.
- Subjects :
- Medicine (General)
medicine.medical_specialty
Cyclophosphamide
medicine.medical_treatment
Case Report
macromolecular substances
030204 cardiovascular system & hematology
Gastroenterology
03 medical and health sciences
R5-920
rituximab
0302 clinical medicine
stomatognathic system
Prednisone
Internal medicine
Intensive care
medicine
030212 general & internal medicine
diffuse alveolar hemorrhage
granulomatosis with polyangiitis
business.industry
Diffuse alveolar hemorrhage
General Medicine
medicine.disease
plasmapheresis
prednisone
cyclophosphamide
Rituximab
Plasmapheresis
Granulomatosis with polyangiitis
Vasculitis
business
medicine.drug
Subjects
Details
- ISSN :
- 16489144
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Medicina
- Accession number :
- edsair.doi.dedup.....c706aefd879ba449c0b28826982a9eb6
- Full Text :
- https://doi.org/10.3390/medicina55070378