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Prenatal particulate air pollution and DNA methylation in newborns: an epigenome-wide meta-analysis

Authors :
Tim S. Nawrot
Cheng Peng
Kelly M. Bakulski
Paul Yousefi
Mariona Bustamante
Lorenzo Richiardi
Josep M. Antó
Erik Melén
Göran Pershagen
Dawn L. DeMeo
Jason I. Feinberg
Cheng-Jian Xu
Gerard H. Koppelman
Carrie V. Breton
Inger Kull
Rosalind J. Wright
Akram Ghantous
Diane R. Gold
Charles Auffray
Michelle Plusquin
Nathanaël Lemonnier
Herman T. den Dekker
Johanna Lepeule
Itai Kloog
Christine Ladd-Acosta
Martine Vrijheid
Olena Gruzieva
Isabella Annesi-Maesano
Bert Brunekreef
Heather E. Volk
Janine F. Felix
José Luis Ruiz
Zdenko Herceg
Stephanie J. London
Allan C. Just
Cilla Söderhäll
Simon Kebede Merid
Lu Gao
Anna Bergström
Regina Grazuleviciene
Jean Bousquet
Vincent W. V. Jaddoe
Andrea A. Baccarelli
Liesbeth Duijts
Jordi Sunyer
Costanza Pizzi
Juha Kere
Caroline L Relton
Franca Rusconi
Manolis Kogevinas
Ulrike Gehring
Kristine B. Gutzkow
Paolo Vineis
Carles Hernandez-Ferrer
STEMM - Stem Cells and Metabolism Research Program
Juha Kere / Principal Investigator
University Management
Research Programs Unit
Karolinska Institutet [Stockholm]
Stockholm County Council
University of Groningen [Groningen]
University of Bristol [Bristol]
University of Southern California (USC)
Johns Hopkins Bloomberg School of Public Health [Baltimore]
Johns Hopkins University (JHU)
University of Michigan [Ann Arbor]
University of Michigan System
European Institute for Systems Biology and Medicine (EISBM)
Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB)
Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)
Hasselt University (UHasselt)
Imperial College London
International Agency for Cancer Research (IACR)
Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven)
University of Turin
Children’s Hospital A. Meyer [Florence, Italy]
Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal)
CIBER de Epidemiología y Salud Pública (CIBERESP)
Erasmus University Medical Center [Rotterdam] (Erasmus MC)
Center for Genomic Regulation (CRG-UPF)
Spanish National Research Council (CSIC)
Hospital del Mar Medical Research Institute [Barcelone, Espagne] (IMIM)
Norwegian Institute of Public Health [Oslo] (NIPH)
Vytautas Magnus University - Vytauto Didziojo Universitetas (VDU)
Boston Children's Hospital
Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP)
Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)
Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR)
Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA)
Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)
Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA)
Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Sachs’ Children and Youth Hospital [Stockholm, Sweden]
King‘s College London
Utrecht University [Utrecht]
Icahn School of Medicine at Mount Sinai [New York] (MSSM)
Harvard Medical School [Boston] (HMS)
Harvard T.H. Chan School of Public Health
Ben-Gurion University of the Negev (BGU)
National Institute of Environmental Health Sciences [Durham] (NIEHS-NIH)
National Institutes of Health [Bethesda] (NIH)
Columbia University [New York]
European Project: 733206,H2020,H2020-SC1-2016-RTD,LIFECYCLE(2017)
European Project
Groningen Research Institute for Asthma and COPD (GRIAC)
Epidemiology
Erasmus MC other
Pediatrics
BARBAGALLO, Maïlys
Early-life stressors and LifeCycle health - LIFECYCLE - - H20202017-01-01 - 2021-12-31 - 733206 - VALID
(7e PC / 2007-206) au titre de la convention de subvention n ° 308333 - le projet HELIX - INCOMING
Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])
Università degli studi di Torino = University of Turin (UNITO)
Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA)
Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)
Source :
Gruzieva, O, Xu, C-J, Yousefi, P, Relton, C, Merid, S K, Breton, C V, Gao, L, Volk, H E, Feinberg, J I, Ladd-Acosta, C, Bakulski, K, Auffray, C, Lemonnier, N, Plusquin, M, Ghantous, A, Herceg, Z, Nawrot, T S, Pizzi, C, Richiardi, L, Rusconi, F, Vineis, P, Kogevinas, M, Felix, J F, Duijts, L, den Dekker, H T, Jaddoe, V W V, Ruiz, J L, Bustamante, M, Antó, J M, Sunyer, J, Vrijheid, M, Gutzkow, K B, Grazuleviciene, R, Hernandez-Ferrer, C, Annesi-Maesano, I, Lepeule, J, Bousquet, J, Bergström, A, Kull, I, Söderhäll, C, Kere, J, BIOS Consortium, Gehring, U, Brunekreef, B, Just, A C, Wright, R J, Peng, C, Gold, D R, Kloog, I, DeMeo, D L & Pershagen, G 2019, ' Prenatal Particulate Air Pollution and DNA Methylation in Newborns : An Epigenome-Wide Meta-Analysis ', Environmental Health Perspectives, vol. 127, no. 5, 057012 . https://doi.org/10.1289/EHP4522, Environmental Health Perspectives, Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2019, 127 (5), pp.057012. ⟨10.1289/EHP4522⟩, Environmental Health Perspectives, 127(5):057012. US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE, Environmental Health Perspectives, 127(5):057012. Public Health Services, US Dept of Health and Human Services, Environmental Health Perspectives, 2019, 127 (5), pp.057012. ⟨10.1289/EHP4522⟩, Recercat. Dipósit de la Recerca de Catalunya, instname, Digital.CSIC. Repositorio Institucional del CSIC
Publication Year :
2019
Publisher :
National Institute of Environmental Health Sciences (NIEHS), 2019.

Abstract

Background: Prenatal exposure to air pollution has been associated with childhood respiratory disease and other adverse outcomes. Epigenetics is a suggested link between exposures and health outcomes. Objectives: We aimed to investigate associations between prenatal exposure to particulate matter (PM) with diameter

Subjects

Subjects :
[SDE] Environmental Sciences
Male
MESH: Air Pollutants
Health, Toxicology and Mutagenesis
[SDV]Life Sciences [q-bio]
MESH: Epigenome
010501 environmental sciences
SUSCEPTIBILITY
Toxicology
LUNG DEVELOPMENT
01 natural sciences
Cohort Studies
Epigenome
0302 clinical medicine
MESH: Pregnancy
MESH: DNA Methylation
MESH: Child
Infants nadons
030212 general & internal medicine
CORD BLOOD
MESH: Maternal Exposure
Child
Public, Environmental & Occupational Health
GENE-EXPRESSION
Air Pollutants
Aire -- Contaminació
MESH: Infant, Newborn
ASSOCIATION
ADN -- Metilació
Fetal Blood
MESH: Infant
3142 Public health care science, environmental and occupational health
3. Good health
Europe
[SDV] Life Sciences [q-bio]
Exposome
PREGNANCY
MESH: Particulate Matter
Maternal Exposure
Meta-analysis
Child, Preschool
DNA methylation
[SDE]Environmental Sciences
Female
Life Sciences & Biomedicine
MESH: Air Pollution
Adolescent
Adverse outcomes
Environmental Sciences & Ecology
Environment
complex mixtures
03 medical and health sciences
Environmental health
Air Pollution
medicine
Humans
MESH: Fetal Blood
Epigenetics
EXPOSURE
Prenatal exposure
0105 earth and related environmental sciences
MESH: Adolescent
Pregnancy
MESH: Humans
Science & Technology
business.industry
Research
MESH: Child, Preschool
R-PACKAGE
Public Health, Environmental and Occupational Health
Infant, Newborn
Infant
CHILDHOOD ASTHMA
Environmental Sciences
DNA Methylation
medicine.disease
Particulate air pollution
MESH: Male
Genòmica
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Gene-Environment Interaction
Particulate Matter
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
business
MESH: Female
MATTER

Details

Language :
English
ISSN :
00916765 and 15529924
Database :
OpenAIRE
Journal :
Gruzieva, O, Xu, C-J, Yousefi, P, Relton, C, Merid, S K, Breton, C V, Gao, L, Volk, H E, Feinberg, J I, Ladd-Acosta, C, Bakulski, K, Auffray, C, Lemonnier, N, Plusquin, M, Ghantous, A, Herceg, Z, Nawrot, T S, Pizzi, C, Richiardi, L, Rusconi, F, Vineis, P, Kogevinas, M, Felix, J F, Duijts, L, den Dekker, H T, Jaddoe, V W V, Ruiz, J L, Bustamante, M, Antó, J M, Sunyer, J, Vrijheid, M, Gutzkow, K B, Grazuleviciene, R, Hernandez-Ferrer, C, Annesi-Maesano, I, Lepeule, J, Bousquet, J, Bergström, A, Kull, I, Söderhäll, C, Kere, J, BIOS Consortium, Gehring, U, Brunekreef, B, Just, A C, Wright, R J, Peng, C, Gold, D R, Kloog, I, DeMeo, D L & Pershagen, G 2019, ' Prenatal Particulate Air Pollution and DNA Methylation in Newborns : An Epigenome-Wide Meta-Analysis ', Environmental Health Perspectives, vol. 127, no. 5, 057012 . https://doi.org/10.1289/EHP4522, Environmental Health Perspectives, Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2019, 127 (5), pp.057012. ⟨10.1289/EHP4522⟩, Environmental Health Perspectives, 127(5):057012. US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE, Environmental Health Perspectives, 127(5):057012. Public Health Services, US Dept of Health and Human Services, Environmental Health Perspectives, 2019, 127 (5), pp.057012. ⟨10.1289/EHP4522⟩, Recercat. Dipósit de la Recerca de Catalunya, instname, Digital.CSIC. Repositorio Institucional del CSIC
Accession number :
edsair.doi.dedup.....c70cb2abd07214615fb55ce14d6a1e9a
Full Text :
https://doi.org/10.1289/EHP4522