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Added value of serial bio-adrenomedullin measurement in addition to lactate for the prognosis of septic patients admitted to ICU
- Source :
- Critical Care, 24, Critical Care, 24, 1, Critical Care, 24(1):69. Springer Science + Business Media, Critical Care, Critical care, Vol. 24, no.1, p. 69 [1-6] (2020), Critical Care, Vol 24, Iss 1, Pp 1-6 (2020), Blet, A, De Roquetaillade, C, Hartmann, O, Struck, J, Mebazaa, A, Chousterman, B G, Laterre, P F, Berghe, C, Dujardin, M F, Renard, S, Wittebole, X, Collienne, C, Zapatero, D C, Dugernier, T, Vinetti, M, De Schryver, N, Thirifays, A, Mairesse, J, Huberlant, V, Petre, H, Buelens, I, Henin, P, Trine, H, Laurent, Y, Sébastien, L, Geukens, P, Kehl, L, François, B, Vignon, P, Pichon, N, Begot, E, Fedou, A L, Chapellas, C, Galy, A, Rodier, N, Baudrillart, L, Nouaille, M, Laleu, S, Mancia, C, Daix, T, Bourzeix, P, Herafa, I, Duchambon, A A, Lascarrou, J B, Fiancette, M, Colin, G, Henry-Lagarrigue, M, Lacherade, J C, Lebert, C, Martin-Levfèvre, L, Vinatier, I, Yehia, A, Bachoumas, K, Joret, A, Reignier, J, Rousseau, C, Maquigneau, N, Alcourt, Y, Zinzonni, V E, Deschamps, A, Robert, A, Mercier, E, Simeon-Vieules, V, Aubrey, A, Mabilat, C, Garot, D, Ehrmann, S, Legras, A, Jouan, Y, Dequin, P F, Guillon, A, Bodet-Contentin, L, Rouve, E, Salmon, C, Brick, L, Massat, S, Desachy, A, Fally, M A, Robin, L, Cracco, C, Lafon, C, Calvat, S, Rouleau, S, Schnell, D, Lasocki, S, Fesard, P, Leblanc, D, Bouhours, G, Chassier, C, Conte, M, Gaillard, T, Denou, F, Kerymel, M, Guyon, M, Loiez, A, Lebreton, S, Meziani, F, Allam, H, Chenaf, S, Rahmani, H, Heenen, S, Kummerlen, C, Delabranche, X, Boivin, A, Clere-Jehl, R, Rabouël, Y, Pottecher, J, Bayer, S, Metzger, C, Hecketsweiler, S, Ludes, P O, Besancenot, H, Dhif, N, Freys, G, Lessinger, J M, Launoy, A, Ruimy, A, Meyer, A, Szozot, M, Mebazaa, A, Deye, N, Gayat, E, Fournier, M C, Abroug, S, Louadah, B, Feliot, E, Voicu, S, Malissin, I, Megarbane, B, Manivet, P, Victori, G, Kelly, D S, La Foucher, B, Pierre, V, Kerdjana, L, Beeken, T, Goury, A, Garcon, P, Gaugain, S, Chousterman, B G, Huot, B, Barthelemy, R, Soyer, B, Jacob, L, Legrand, M, Fourniar, M C, Bonnet, F, Legall, C, Oueslati, H, Cupaciu, A, Manivat, P, Louadeh, B, Sonneville, R, Letrou, S, Bouadma, L, Mourvillier, B, Deiler, V, Magalhaes, E, Neuville, M, Timsit, J F, Radjou, A, Gaudry, S, Dubief, E, Messika, J, La Combe, B, Roux, D, Berquier, G, Laissi, M, Ricard, J D, Constantin, J M, Perbet, S, Delmas, J, Pascal, J, Cayot, S, Guerin, R, Jabaudon, M, Roszyk, L, Rolhion, C, Bourdier, J, Lematte, M, Gouhier, C, Verlhac, C, Godet, T, Radji, S, Caumon, E, Thibault, S, Marx, N, Schuerholz, T, Pezechk, J, Feld, F, Brülls, C, Beeker, T, Simon, T P, Deisz, R, Schindler, A, Meier, B, Janisch, T, Hohn, A, Schedler, D, Wetsch, W, Schröder, D, Meier-Hellmann, A, Lucht, A, Henker, R, Römmer, M, Meinig, T, Zacharowski, K D, Meybohm, P, Lindau, S, Mutlak, H, Kluge, S, Ringeis, G, Füllekrug, B, Singer, B, Nierhaus, A, Bangert, K, De Heer, G, Frings, D, Fuhrmann, V, Müller, J, Schreiber, J, Sensen, B, Siedler, S, Siewecke, A, Söffker, G, Wichmann, D, Kerinn, M, Jaschinski, U, Kreuser, I, Zanquila, M, Kortgen, A, Bloos, F, Gonnert, F, Thomas-Rüddel, D, Haucke, A, Kolanos, S, Kohlberg, K K, Bloos, P, Schwope, K, Di Somma, S, Rossella, M, Russo, V, Simona, S, Bartoli, C, Navarin, S, Bongiovanni, C, Orru, M, Quatrocchi, D, Zoccoli, G, Varchetta, A, Antonelli, M, De Pascale, G, Vallecoccia, M S, Cutuli, S L, Digravio, V, Quattrochi, D, D'Arrigo, S, Leone, F E, Beishuizen, B, Rinket, M, Border, N, Bos-Burgmeijer, M, Braad, A, Papendorp, S, Vermeijden, J, Pickkers, P, Van De A, M, Van Wezel, H, Heunks, L, Bordar, N, Luijten-Arts, C, Hoedemaekers, A, Van Der Hoeven, H, Roovers, N & Hemelaar, P 2020, ' Added value of serial bio-adrenomedullin measurement in addition to lactate for the prognosis of septic patients admitted to ICU ', Critical Care, vol. 24, no. 1, 69 . https://doi.org/10.1186/s13054-020-2794-x
- Publication Year :
- 2020
-
Abstract
- Adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure and a direct relationship with vasopressor requirement. In the present prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock 1 (, AdrenOSS-1) study, we assessed relationships between circulating bio-ADM during the initial intensive care unit (ICU) stay and short-term outcome in order to eventually design a biomarker-guided randomized controlled trial.AdrenOSS-1 was a prospective observational multinational study. The primary outcome was 28-day mortality. Secondary outcomes included organ failure as defined by Sequential Organ Failure Assessment (SOFA) score, organ support with focus on vasopressor/inotropic use, and need for renal replacement therapy. AdrenOSS-1 included 583 patients admitted to the ICU with sepsis or septic shock.Circulating bio-ADM levels were measured upon admission and at day 2. Median bio-ADM concentration upon admission was 80.5 pg/ml [IQR 41.5-148.1 pg/ml]. Initial SOFA score was 7 [IQR 5-10], and 28-day mortality was 22%. We found marked associations between bio-ADM upon admission and 28-day mortality (unadjusted standardized HR 2.3 [CI 1.9-2.9]; adjusted HR 1.6 [CI 1.1-2.5]) and between bio-ADM levels and SOFA score (p0.0001). Need of vasopressor/inotrope, renal replacement therapy, and positive fluid balance were more prevalent in patients with a bio-ADM70 pg/ml upon admission than in those with bio-ADM ≤ 70 pg/ml. In patients with bio-ADM70 pg/ml upon admission, decrease in bio-ADM below 70 pg/ml at day 2 was associated with recovery of organ function at day 7 and better 28-day outcome (9.5% mortality). By contrast, persistently elevated bio-ADM at day 2 was associated with prolonged organ dysfunction and high 28-day mortality (38.1% mortality, HR 4.9, 95% CI 2.5-9.8).AdrenOSS-1 shows that early levels and rapid changes in bio-ADM estimate short-term outcome in sepsis and septic shock. These data are the backbone of the design of the biomarker-guided AdrenOSS-2 trial.ClinicalTrials.gov, NCT02393781 . Registered on March 19, 2015.
- Subjects :
- Male
medicine.medical_specialty
Multiple Organ Failure
MEDLINE
lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]
Critical Care and Intensive Care Medicine
Sepsis
03 medical and health sciences
Adrenomedullin
0302 clinical medicine
Belgium
Germany
medicine
Research Letter
Humans
Lactic Acid
Hospital Mortality
Prospective Studies
Prospective cohort study
Aged
Netherlands
Proportional Hazards Models
Chi-Square Distribution
business.industry
lcsh:Medical emergencies. Critical care. Intensive care. First aid
030208 emergency & critical care medicine
lcsh:RC86-88.9
Length of Stay
Middle Aged
medicine.disease
Prognosis
Shock, Septic
Survival Analysis
3. Good health
Hospitalization
Patient Outcome Assessment
Intensive Care Units
030228 respiratory system
Italy
Shock (circulatory)
Emergency medicine
Female
France
medicine.symptom
business
Biomarkers
Subjects
Details
- ISSN :
- 13648535 and 1466609X
- Database :
- OpenAIRE
- Journal :
- Critical Care, 24, Critical Care, 24, 1, Critical Care, 24(1):69. Springer Science + Business Media, Critical Care, Critical care, Vol. 24, no.1, p. 69 [1-6] (2020), Critical Care, Vol 24, Iss 1, Pp 1-6 (2020), Blet, A, De Roquetaillade, C, Hartmann, O, Struck, J, Mebazaa, A, Chousterman, B G, Laterre, P F, Berghe, C, Dujardin, M F, Renard, S, Wittebole, X, Collienne, C, Zapatero, D C, Dugernier, T, Vinetti, M, De Schryver, N, Thirifays, A, Mairesse, J, Huberlant, V, Petre, H, Buelens, I, Henin, P, Trine, H, Laurent, Y, Sébastien, L, Geukens, P, Kehl, L, François, B, Vignon, P, Pichon, N, Begot, E, Fedou, A L, Chapellas, C, Galy, A, Rodier, N, Baudrillart, L, Nouaille, M, Laleu, S, Mancia, C, Daix, T, Bourzeix, P, Herafa, I, Duchambon, A A, Lascarrou, J B, Fiancette, M, Colin, G, Henry-Lagarrigue, M, Lacherade, J C, Lebert, C, Martin-Levfèvre, L, Vinatier, I, Yehia, A, Bachoumas, K, Joret, A, Reignier, J, Rousseau, C, Maquigneau, N, Alcourt, Y, Zinzonni, V E, Deschamps, A, Robert, A, Mercier, E, Simeon-Vieules, V, Aubrey, A, Mabilat, C, Garot, D, Ehrmann, S, Legras, A, Jouan, Y, Dequin, P F, Guillon, A, Bodet-Contentin, L, Rouve, E, Salmon, C, Brick, L, Massat, S, Desachy, A, Fally, M A, Robin, L, Cracco, C, Lafon, C, Calvat, S, Rouleau, S, Schnell, D, Lasocki, S, Fesard, P, Leblanc, D, Bouhours, G, Chassier, C, Conte, M, Gaillard, T, Denou, F, Kerymel, M, Guyon, M, Loiez, A, Lebreton, S, Meziani, F, Allam, H, Chenaf, S, Rahmani, H, Heenen, S, Kummerlen, C, Delabranche, X, Boivin, A, Clere-Jehl, R, Rabouël, Y, Pottecher, J, Bayer, S, Metzger, C, Hecketsweiler, S, Ludes, P O, Besancenot, H, Dhif, N, Freys, G, Lessinger, J M, Launoy, A, Ruimy, A, Meyer, A, Szozot, M, Mebazaa, A, Deye, N, Gayat, E, Fournier, M C, Abroug, S, Louadah, B, Feliot, E, Voicu, S, Malissin, I, Megarbane, B, Manivet, P, Victori, G, Kelly, D S, La Foucher, B, Pierre, V, Kerdjana, L, Beeken, T, Goury, A, Garcon, P, Gaugain, S, Chousterman, B G, Huot, B, Barthelemy, R, Soyer, B, Jacob, L, Legrand, M, Fourniar, M C, Bonnet, F, Legall, C, Oueslati, H, Cupaciu, A, Manivat, P, Louadeh, B, Sonneville, R, Letrou, S, Bouadma, L, Mourvillier, B, Deiler, V, Magalhaes, E, Neuville, M, Timsit, J F, Radjou, A, Gaudry, S, Dubief, E, Messika, J, La Combe, B, Roux, D, Berquier, G, Laissi, M, Ricard, J D, Constantin, J M, Perbet, S, Delmas, J, Pascal, J, Cayot, S, Guerin, R, Jabaudon, M, Roszyk, L, Rolhion, C, Bourdier, J, Lematte, M, Gouhier, C, Verlhac, C, Godet, T, Radji, S, Caumon, E, Thibault, S, Marx, N, Schuerholz, T, Pezechk, J, Feld, F, Brülls, C, Beeker, T, Simon, T P, Deisz, R, Schindler, A, Meier, B, Janisch, T, Hohn, A, Schedler, D, Wetsch, W, Schröder, D, Meier-Hellmann, A, Lucht, A, Henker, R, Römmer, M, Meinig, T, Zacharowski, K D, Meybohm, P, Lindau, S, Mutlak, H, Kluge, S, Ringeis, G, Füllekrug, B, Singer, B, Nierhaus, A, Bangert, K, De Heer, G, Frings, D, Fuhrmann, V, Müller, J, Schreiber, J, Sensen, B, Siedler, S, Siewecke, A, Söffker, G, Wichmann, D, Kerinn, M, Jaschinski, U, Kreuser, I, Zanquila, M, Kortgen, A, Bloos, F, Gonnert, F, Thomas-Rüddel, D, Haucke, A, Kolanos, S, Kohlberg, K K, Bloos, P, Schwope, K, Di Somma, S, Rossella, M, Russo, V, Simona, S, Bartoli, C, Navarin, S, Bongiovanni, C, Orru, M, Quatrocchi, D, Zoccoli, G, Varchetta, A, Antonelli, M, De Pascale, G, Vallecoccia, M S, Cutuli, S L, Digravio, V, Quattrochi, D, D'Arrigo, S, Leone, F E, Beishuizen, B, Rinket, M, Border, N, Bos-Burgmeijer, M, Braad, A, Papendorp, S, Vermeijden, J, Pickkers, P, Van De A, M, Van Wezel, H, Heunks, L, Bordar, N, Luijten-Arts, C, Hoedemaekers, A, Van Der Hoeven, H, Roovers, N & Hemelaar, P 2020, ' Added value of serial bio-adrenomedullin measurement in addition to lactate for the prognosis of septic patients admitted to ICU ', Critical Care, vol. 24, no. 1, 69 . https://doi.org/10.1186/s13054-020-2794-x
- Accession number :
- edsair.doi.dedup.....c70f8ef761b7c1230042250428ef9fca
- Full Text :
- https://doi.org/10.1186/s13054-020-2794-x