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Corticosteroids in oncology: Use, overuse, indications, contraindications. An Italian Association of Medical Oncology (AIOM)/ Italian Association of Medical Diabetologists (AMD)/ Italian Society of Endocrinology (SIE)/ Italian Society of Pharmacology (SIF) multidisciplinary consensus position paper

Corticosteroids in oncology: Use, overuse, indications, contraindications. An Italian Association of Medical Oncology (AIOM)/ Italian Association of Medical Diabetologists (AMD)/ Italian Society of Endocrinology (SIE)/ Italian Society of Pharmacology (SIF) multidisciplinary consensus position paper

Authors :
Antongiulio Faggiano
Rossella Mazzilli
Annalisa Natalicchio
Valerio Adinolfi
Antonella Argentiero
Romano Danesi
Stella D’Oronzo
Stefano Fogli
Marco Gallo
Dario Giuffrida
Stefania Gori
Monica Montagnani
Alberto Ragni
Valerio Renzelli
Antonio Russo
Nicola Silvestris
Tindara Franchina
Enzo Tuveri
Saverio Cinieri
Annamaria Colao
Francesco Giorgino
Maria Chiara Zatelli
Faggiano A.
Mazzilli R.
Natalicchio A.
Adinolfi V.
Argentiero A.
Danesi R.
D'Oronzo S.
Fogli S.
Gallo M.
Giuffrida D.
Gori S.
Montagnani M.
Ragni A.
Renzelli V.
Russo A.
Silvestris N.
Franchina T.
Tuveri E.
Cinieri S.
Colao A.
Giorgino F.
Zatelli M.C.
Publication Year :
2022
Publisher :
Elsevier Ireland Ltd, 2022.

Abstract

Corticosteroids (CSs) are widely used in oncology, presenting several different indications. They are useful for induction of apoptosis in hematological neoplasms, for management of anaphylaxis and cytokine release/hypersensitivity reaction and for the symptomatic treatment of many tumour- and treatment-related complications. If the employment of CSs in the oncological setting results in several benefits for patients and satisfaction for clinicians, on the other hand, many potential adverse events (AEs), both during treatment and after withdrawal of CSs, as well as the duality of the effects of these compounds in oncology, recommend being cautious in clinical practice. To date, several gray zones remain about indications, contraindications, dose, and duration of treatment. In this article, a panel of experts provides a critical review on CSs therapy in oncology, focusing on mechanisms of action and pharmacological characteristics, current and emerging therapeutic indications/contraindications, AEs related to CSs treatment, and the impact on patient outcome.

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....c71469634d1382fbe98f1cf3003e9aa7