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Immunosuppressive retroviral peptides: cAMP and cytokine patterns

Authors :
Robert A. Good
Soichi Haraguchi
Noorbibi K. Day
Source :
Immunology Today. 16:595-603
Publication Year :
1995
Publisher :
Elsevier BV, 1995.

Abstract

The mechanism(s) by which retroviral proteins exert immunosuppressive influences has remained enigmatic. Here, Soichi Haraguchi, Robert Good and Noorbibi Day propose that induction of intracellular cAMP by a synthetic, immunosuppressive, retroviral envelope peptide causes a shift in the cytokine balance, leading to suppression of cell-mediated immunity by upregulation of interleukin 10 (IL-10) and downregulation of IL-2, IL-12 and tumor necrosis factor α production. This may be a crucial step towards generation of immune dysfunction.

Details

ISSN :
01675699
Volume :
16
Database :
OpenAIRE
Journal :
Immunology Today
Accession number :
edsair.doi.dedup.....c7157733f81b20fdb7197dbee986031a
Full Text :
https://doi.org/10.1016/0167-5699(95)80083-2