Back to Search
Start Over
Influence of the estrous cycle on tolerance development to LPS-induced sickness behaviors in rats
- Source :
- Psychoneuroendocrinology. 31:510-525
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- Summary The relations between the estrous cycle, inflammatory responses and the development of tolerance to endotoxin were examined. Female Long-Evans rats were injected intraperitoneally with lipopolysaccharide (LPS; 200 μg/kg) or saline vehicle at 08:00 h on either diestrus (D) or proestrus (P). Ninety‐five minutes after injection locomotor activity was assessed in an automated non-novel open-field for 20 min. To assess tolerance development to LPS, rats were re-injected at the next identical stage (i.e. 4 days later; groups: DD, PP) or at the alternate stage (i.e. 6 days later; groups: DP, PD) of the estrous cycle and locomotor activity was again assessed. On Test Day 1 all groups injected with LPS exhibited similar significant activity decrements, regardless of the stage of the estrous cycle. However, on Test Day 2 rats which received both injections of LPS during proestrus (PP) showed no signs of tolerance development, whereas rats in all other groups were tolerant to LPS. In a follow up study, the time between injections was extended to 8 days. Still the animals injected both times at proestrus showed no signs of tolerance to LPS after the second injection. Thus, the stages of the estrous cycle both at the time of initial exposure and of re-exposure appear critical in the formation of behavioral tolerance to LPS in rats.
- Subjects :
- Lipopolysaccharides
Male
endocrine system
medicine.medical_specialty
Lipopolysaccharide
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Estrous Cycle
Inflammation
Motor Activity
Locomotor activity
Statistics, Nonparametric
Open field
chemistry.chemical_compound
Endocrinology
Internal medicine
Immune Tolerance
medicine
Animals
Rats, Long-Evans
Saline
Progesterone
Biological Psychiatry
Estrous cycle
Analysis of Variance
Behavior, Animal
Estradiol
Endocrine and Autonomic Systems
business.industry
Sick Role
Follow up studies
Rats
Psychiatry and Mental health
Test day
chemistry
medicine.symptom
Corticosterone
business
Subjects
Details
- ISSN :
- 03064530
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Psychoneuroendocrinology
- Accession number :
- edsair.doi.dedup.....c7272c453ab1e9a2311d1024c7646d68