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New γ-pyrone glycoside from Pachira glabra and assessment of its gastroprotective activity using an alcohol-induced gastric ulcer model in rats
- Source :
- Food & Function. 11:1958-1965
- Publication Year :
- 2020
- Publisher :
- Royal Society of Chemistry (RSC), 2020.
-
Abstract
- Pachira glabra is a medium sized tree that is famous for its delicious edible seeds and leaves. Phytochemical investigation of Pachira glabra leaf alcohol extract led to the isolation of a new γ-pyrone glycoside, 7-hydroxy maltol-3-O-β-d-glucoside (HMGlu). In vivo assessment of the gastro-protective activity of HMGlu demonstrated superior gastro-protection at a dose of 100 mg kg-1, close to the value triggered by the standard reference omeprazole drug (evidenced by morphological and histopathological examinations). This was further confirmed by immunohistochemical staining where pretreatment with HMGlu (100 mg kg-1) markedly reduced NFκB, COX-2 and BAX positively-stained cells. Thus, it can be concluded that 7-hydroxy maltol-3-O-β-d-glucoside can be a new pharmaceutically active agent with promising gastro-protective activity of natural origin.
- Subjects :
- Male
0301 basic medicine
Pachira glabra
Alcohol
01 natural sciences
03 medical and health sciences
chemistry.chemical_compound
In vivo
Bombacaceae
medicine
Animals
Glycosides
Stomach Ulcer
Rats, Wistar
Omeprazole
chemistry.chemical_classification
Ethanol
Traditional medicine
Plant Extracts
Glycoside
General Medicine
Anti-Ulcer Agents
Pyrone
Rats
0104 chemical sciences
Disease Models, Animal
010404 medicinal & biomolecular chemistry
030104 developmental biology
Phytochemical
chemistry
Gastric Mucosa
Food Science
medicine.drug
Subjects
Details
- ISSN :
- 2042650X and 20426496
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Food & Function
- Accession number :
- edsair.doi.dedup.....c72f6c9e07f8b67f2d6583069eecc427