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Exercise during weight loss improves hepatic mitophagy
- Source :
- Sports Medicine and Health Science. 4:183-189
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Non-alcoholic fatty liver disease (NAFLD) has recently become a public health concern concurrent with the obesity crisis. Previous work has shown aberrant mitochondrial content/quality and autophagy in models of NAFLD, whereas exercise is known to improve these derangements. The purpose of this study was to examine the effect of different weight-loss modalities on hepatic mitochondrial content, autophagy and mitophagy in NAFLD. Forty-eight male C57BL/6J mice were divided into 1 of 4 groups: low fat diet (LFD, 10% fat, 18 weeks), high fat diet (HFD, 60% fat diet, 18 weeks), weight-loss by diet (D, 60% fat diet for 10 weeks then 10% fat diet for 8 weeks) or weight-loss by diet and physical activity (D/PA, 60% fat diet for 10 weeks, then 10% fat diet plus a running wheel for 8 weeks). Immunoblot data were analyzed by one-way analysis of variance (ANOVA) with significance denoted at
Details
- ISSN :
- 26663376
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Sports Medicine and Health Science
- Accession number :
- edsair.doi.dedup.....c73435d33e3b2a1ebdec3723acae29ba