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Evaluation of a New Hydroxyapatite Nanoparticle as a Drug Delivery System to Oral Squamous Cell Carcinoma Cells
- Source :
- Anticancer Research. 38:6715-6720
- Publication Year :
- 2018
- Publisher :
- Anticancer Research USA Inc., 2018.
-
Abstract
- Background/aim Due to its abilities of substance adsorption and intracellular transportation, hydroxyapatite is a potential carrier in drug delivery systems (DDS). This in vitro study investigated whether newly-developed, highly-dispersive calcined hydroxyapatite nanoparticles with an average grain diameter of 20 nm (nano-SHAP) were suitable as a DDS for the drugs zoledronic acid (ZA), cisplatin, and carboplatin. Material and methods The effects of drug-bearing nano-SHAP on cell proliferation were assessed using three human oral squamous cell carcinoma cell lines (HSC-4, KOSC, and SAS) and one human breast cancer cell line (MCF-7). Results Nano-SHAP alone did not affect proliferation of any cell line until a concentration of 1 μg/ml was reached. Although the effective concentration of ZA in ZA-bearing nano-SHAP differed, it inhibited cell proliferation better than ZA alone. Cisplatin and carboplatin-bearing nano-SHAP had the same effect as these drugs alone. Conclusion The nano-SHAP system is of potential use as a drug delivery system.
- Subjects :
- 0301 basic medicine
Cancer Research
medicine.medical_treatment
Zoledronic Acid
03 medical and health sciences
chemistry.chemical_compound
Drug Delivery Systems
Cell Line, Tumor
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Cell Proliferation
Cisplatin
Drug Carriers
Dose-Response Relationship, Drug
Cell growth
Chemistry
General Medicine
Bisphosphonate
Carboplatin
Durapatite
030104 developmental biology
Zoledronic acid
Oncology
Cell culture
Drug delivery
Carcinoma, Squamous Cell
MCF-7 Cells
Cancer research
Nanoparticles
Mouth Neoplasms
Intracellular
medicine.drug
Subjects
Details
- ISSN :
- 17917530 and 02507005
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Anticancer Research
- Accession number :
- edsair.doi.dedup.....c73b7f819766780a00350c6074815569