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Association study of CREBRF missense variant (rs373863828:G A; p.Arg457Gln) with levels of serum lipid profile in the Pacific populations
- Source :
- Annals of human biology. 45(3)
- Publication Year :
- 2018
-
Abstract
- A missense variant (rs373863828:G A; p.Arg457Gln) of the CREBRF gene is strongly associated with a higher body mass index (BMI; kg/mThe aim of this study is to examine the association of rs373863828:G A with levels of serum lipids in four Pacific populations.A total of 613 adult subjects were recruited from Tonga (Polynesians) and the Solomon Islands (Melanesians and Micronesians). Multiple regression analyses adjusted for age and sex were performed to examine the association of rs373863828 with levels of serum lipids in each population.A significant association of rs373863828:G A with lower level of HDL-cholesterol was detected in the Tonga population (β = -3.32 and p-value = 0.030). The expected change in HDL-cholesterol with respect to a single copy of the rs373863828-A allele was 3.32 mg/dL. However, the association between rs373863828-A and lower levels of HDL-cholesterol was not significant after further adjustment for BMI in the Tonga population (β = -2.32 and p-value = 0.13).The rs373863828-A allele may not directly affect the level of serum HDL-cholesterol independent of BMI. To confirm the present findings, association studies with large sample sizes and functional analyses are required.
- Subjects :
- 0301 basic medicine
Adult
Male
Aging
medicine.medical_specialty
Physiology
Epidemiology
Mutation, Missense
Biology
03 medical and health sciences
Young Adult
0302 clinical medicine
Internal medicine
Genetics
medicine
Missense mutation
Humans
Triglycerides
Aged
medicine.diagnostic_test
Tumor Suppressor Proteins
Cholesterol, HDL
Tonga
Public Health, Environmental and Occupational Health
CREBRF gene
Cholesterol, LDL
Middle Aged
030104 developmental biology
Endocrinology
Female
Melanesia
Lipid profile
Body mass index
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14645033
- Volume :
- 45
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Annals of human biology
- Accession number :
- edsair.doi.dedup.....c773185736e8253d893515a514bd640e