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Procalcitonin and C - reactive protein as peripheral inflammatory markers in antipsychotic drug-free schizophrenia patients
- Source :
- Asian journal of psychiatry. 35
- Publication Year :
- 2018
-
Abstract
- Inflammation is considered to be relevant in pathophysiology of schizophrenia. Existing literature indicates that controlling inflammation may be helpful in patient management. Procalcitonin (PCT) is an established marker of inflammation which has not been well studied in context with schizophrenia. The study recruited 34 schizophrenia patients free of antipsychotic treatment and 24 healthy controls without any signs of inflammation. Plasma C reactive protein was quantified using a high sensitivity turbidimetric assay. Plasma PCT levels was estimated by sandwich ELISA. The study ruled out autoimmune antibodies by ANA and RF tests which exclude confounding factors contributing to inflammation. The data shows a subgroup of patients 17/34 (50%) have either elevated PCT or CRP levels. This study is the first to report PCT values in antipsychotic drug-free patients with schizophrenia.
- Subjects :
- Adult
Calcitonin
Male
medicine.medical_specialty
Anti-nuclear antibody
medicine.medical_treatment
Inflammation
Context (language use)
Gastroenterology
Procalcitonin
03 medical and health sciences
Young Adult
0302 clinical medicine
Internal medicine
parasitic diseases
medicine
Humans
Antipsychotic
General Psychology
biology
business.industry
C-reactive protein
General Medicine
medicine.disease
Pathophysiology
030227 psychiatry
Psychiatry and Mental health
C-Reactive Protein
Schizophrenia
biology.protein
Female
medicine.symptom
business
hormones, hormone substitutes, and hormone antagonists
030217 neurology & neurosurgery
Biomarkers
Subjects
Details
- ISSN :
- 18762026
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Asian journal of psychiatry
- Accession number :
- edsair.doi.dedup.....c775cddac8c1ff204fcf9565516adc34