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Age-specific anti-Müllerian hormone and electrocardiographic silent coronary artery disease
- Source :
- Climacteric, 19(4), 344. Informa Healthcare
- Publication Year :
- 2016
-
Abstract
- Objective: To explore the relationship between age-specific anti-Müllerian hormone level, as a predictor of ovarian reserve status, and electrocardiographic silent coronary artery disease in a population-based, prospective cohort, the Tehran Lipid and Glucose Study. Methods: For the present study, 1015 reproductive-aged participants in the Tehran Lipid and Glucose Study met our eligibility criteria. According to the Whitehall criteria, silent coronary artery disease was defined as an electrocardiogram showing possible or probable coronary heart disease using Minnesota codes. By excluding those with a history of coronary heart disease and silent coronary artery disease at the initiation of the study (n = 49), there were 108 events of silent coronary artery disease at electrocardiograms among 752 women followed for 9.5 ± 0.9 years (missing data: n = 214); the association between this outcome with age-specific anti-Müllerian hormone levels was explored after adjustment for confounding variables using logistic regression analysis. Cardiovascular disease risk scores were assessed for all participants using the guidelines of the American College of Cardiology and the American Heart Association. Results: There were 108 events of silent coronary artery disease over the 10-year follow-up. Logistic regression analysis, considering age-specific anti-Müllerian hormone and atherosclerotic cardiovascular disease risk score as independent variables, revealed an odds ratio of 1.146 (95% confidence interval 1.008–1.303) for cardiovascular disease risk score (p = 0.038) and odds ratio of 1.002 (95% confidence interval 0.996–1.009) for age-specific anti-Müllerian hormone (p = 0.526). Conclusion: No association has been found between age-specific anti-Müllerian hormone levels and events of silent coronary artery disease in a 10-year follow-up of reproductive-aged women.
- Subjects :
- Anti-Mullerian Hormone
Coronary Artery Disease
030204 cardiovascular system & hematology
Iran
Anti-Müllerian hormone
ACC/AHA risk score
Coronary artery disease
ovarian reserve
0302 clinical medicine
Risk Factors
Obstetrics and Gynaecology
Prospective Studies
Prospective cohort study
030219 obstetrics & reproductive medicine
Framingham Risk Score
biology
medicine.diagnostic_test
Confounding
Age Factors
Obstetrics and Gynecology
General Medicine
atherosclerotic cardiovascular disease (ASCVD) risk score
cohort
Middle Aged
Cohort
Cardiology
Female
Adult
medicine.medical_specialty
electrocardiography
Risk Assessment
03 medical and health sciences
Internal medicine
medicine
Journal Article
Humans
silent coronary artery disease
Ovarian reserve
business.industry
medicine.disease
Atherosclerosis
cardiovascular diseases
Logistic Models
biology.protein
business
Electrocardiography
Biomarkers
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 13697137
- Volume :
- 19
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Climacteric
- Accession number :
- edsair.doi.dedup.....c78d814bd194d9258ffbd826adf5ed92