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An increased body mass index is associated with a worse prognosis in patients administered BCG immunotherapy for T1 bladder cancer
- Source :
- World journal of urology (Internet) (2018): 1–8. doi:10.1007/s00345-018-2397-1, info:cnr-pdr/source/autori:Ferro M.; Vartolomei M.D.; Russo G.I.; Cantiello F.; Farhan A.R.A.; Terracciano D.; Cimmino A.; Di Stasi S.; Musi G.; Hurle R.; Serretta V.; Busetto G.M.; de Berardinis E.; Cioffi A.; Perdona S.; Borghesi M.; Schiavina R.; Cozzi G.; Almeida G.L.; Bove P.; Lima E.; Grimaldi G.; Matei D.V.; Crisan N.; Muto M.; Verze P.; Battaglia M.; Guazzoni G.; Autorino R.; Morgia G.; Damiano R.; de Cobelli O.; Shariat S.; Mirone V.; Lucarelli G./titolo:An increased body mass index is associated with a worse prognosis in patients administered BCG immunotherapy for T1 bladder cancer/doi:10.1007%2Fs00345-018-2397-1/rivista:World journal of urology (Internet)/anno:2018/pagina_da:1/pagina_a:8/intervallo_pagine:1–8/volume, Translational Andrology and Urology, Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP
- Publication Year :
- 2019
-
Abstract
- PURPOSE: The body mass index (BMI) may be associated with an increased incidence and aggressiveness of urological cancers. In this study, we aimed to evaluate the impact of the BMI on survival in patients with T1G3 non-muscle-invasive bladder cancer (NMIBC). METHODS: A total of 1155 T1G3 NMIBC patients from 13 academic institutions were retrospectively reviewed and patients administered adjuvant intravesical Bacillus Calmette-Guérin (BCG) immunotherapy with maintenance were included. Multivariable Cox regression analysis was performed to identify factors predictive of recurrence and progression. RESULTS: After re-TURBT, 288 patients (27.53%) showed residual high-grade NMIBC, while 867 (82.89%) were negative. During follow-up, 678 (64.82%) suffered recurrence, and 303 (30%) progression, 150 (14.34%) died of all causes, and 77 (7.36%) died of bladder cancer. At multivariate analysis, tumor size (hazard ratio [HR]:1.3; p = 0.001), and multifocality (HR:1.24; p = 0.004) were significantly associated with recurrence (c-index for the model:55.98). Overweight (HR: 4; p<br />M.D.V is supported by the Scholarship Foundation of the Republic of Austria—OeAD and by the EUSP Scholarship— European Association of Urology<br />info:eu-repo/semantics/publishedVersion
- Subjects :
- Male
medicine.medical_treatment
Prognosis
030232 urology & nephrology
Comorbidity
Gastroenterology
Settore MED/24 - Urologia
0302 clinical medicine
Bladder cancer
Body mass index
Obesity
Medicine
Aged, 80 and over
Hazard ratio
Cystoscopy
Middle Aged
Tumor Burden
Administration, Intravesical
Editorial
Transitional cell carcinoma
Chemotherapy, Adjuvant
030220 oncology & carcinogenesis
BCG Vaccine
Disease Progression
Female
medicine.medical_specialty
Prognosi
Urology
Cystectomy
Disease-Free Survival
03 medical and health sciences
Adjuvants, Immunologic
Internal medicine
Humans
Mortality
Aged
Neoplasm Staging
Proportional Hazards Models
Retrospective Studies
Cancer staging
Carcinoma, Transitional Cell
Science & Technology
business.industry
Proportional hazards model
medicine.disease
Urinary Bladder Neoplasms
Concomitant
Multivariate Analysis
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- World journal of urology (Internet) (2018): 1–8. doi:10.1007/s00345-018-2397-1, info:cnr-pdr/source/autori:Ferro M.; Vartolomei M.D.; Russo G.I.; Cantiello F.; Farhan A.R.A.; Terracciano D.; Cimmino A.; Di Stasi S.; Musi G.; Hurle R.; Serretta V.; Busetto G.M.; de Berardinis E.; Cioffi A.; Perdona S.; Borghesi M.; Schiavina R.; Cozzi G.; Almeida G.L.; Bove P.; Lima E.; Grimaldi G.; Matei D.V.; Crisan N.; Muto M.; Verze P.; Battaglia M.; Guazzoni G.; Autorino R.; Morgia G.; Damiano R.; de Cobelli O.; Shariat S.; Mirone V.; Lucarelli G./titolo:An increased body mass index is associated with a worse prognosis in patients administered BCG immunotherapy for T1 bladder cancer/doi:10.1007%2Fs00345-018-2397-1/rivista:World journal of urology (Internet)/anno:2018/pagina_da:1/pagina_a:8/intervallo_pagine:1–8/volume, Translational Andrology and Urology, Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP
- Accession number :
- edsair.doi.dedup.....c7af93bd218178876c6ee715cc51e86f