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Studies on the Regulatory Roles and Related Mechanisms of lncRNAs in the Nervous System
- Source :
- Oxidative Medicine and Cellular Longevity, Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
- Publication Year :
- 2021
- Publisher :
- Hindawi Limited, 2021.
-
Abstract
- Long noncoding RNAs (lncRNAs) have attracted extensive attention due to their regulatory role in various cellular processes. Emerging studies have indicated that lncRNAs are expressed to varying degrees after the growth and development of the nervous system as well as injury and degeneration, thus affecting various physiological processes of the nervous system. In this review, we have compiled various reported lncRNAs related to the growth and development of central and peripheral nerves and pathophysiology (including advanced nerve centers, spinal cord, and peripheral nervous system) and explained how these lncRNAs play regulatory roles through their interactions with target-coding genes. We believe that a full understanding of the regulatory function of lncRNAs in the nervous system will contribute to understand the molecular mechanism of changes after nerve injury and will contribute to discover new diagnostic markers and therapeutic targets for nerve injury diseases.
- Subjects :
- Nervous system
Aging
Review Article
Biology
Nervous System
Biochemistry
Neural Stem Cells
medicine
Animals
Humans
QH573-671
Cell Differentiation
Diagnostic marker
Cell Biology
General Medicine
Nerve injury
Nerve Regeneration
medicine.anatomical_structure
Peripheral nervous system
Molecular mechanism
RNA, Long Noncoding
Nervous System Diseases
medicine.symptom
Cytology
Neuroscience
Function (biology)
Subjects
Details
- ISSN :
- 19420994 and 19420900
- Volume :
- 2021
- Database :
- OpenAIRE
- Journal :
- Oxidative Medicine and Cellular Longevity
- Accession number :
- edsair.doi.dedup.....c7c09fdb9b5ff38df6ba46c5d0445505