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A high IL-4 production diplotype is associated with an increased risk but better prognosis of oral and pharyngeal carcinomas
- Source :
- Archives of Oral Biology. 59:35-46
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Interleukin (IL)-4 is a key cytokine in humoral and adaptive immunity. This study aimed to evaluate the association of IL-4 genetic variants (-590CT and VNTR in intron 3) with the risk and prognosis of oral and pharyngeal squamous cell carcinoma (OPSCC).A total of 1215 subjects, which included 623 healthy controls and 592 OPSCC cases (463 oral squamous cell carcinoma (OSCC) and 129 pharyngeal squamous cell carcinoma (PSCC) cases), were recruited. The genotypes were determined by TaqMan real-time assay and PCR-based assay.The IL-4 genotypes at locus -590CT and intron 3 VNTR were not correlated with increased risk of OSCC, PSCC, and OPSCC, with the exception of early-stage OPSCC (at -590CT: T/T vs. C/C+C/T, adjusted odds ratio (AOR)=1.42, 95% CI: 1.02-1.98; at intron 3 VNTR: RP1/RP1 vs. RP2/RP2+RP2/RP1, AOR=1.46, 95% CI: 1.05-2.04). Compared with other IL-4 diplotypes, the T,RP1/T,RP1 diplotype was associated with an increased risk of OPSCC (AOR=1.37, 95% CI: 1.03-1.81), particularly early-stage OSCC (AOR=1.43, 95% CI: 1.02-2.00), PSCC (AOR=2.35, 95% CI: 1.06-5.19), and OPSCC (AOR=1.52, 95% CI: 1.10-2.11). Interactions between the IL-4 diplotype and the alcohol drinking status were found to contribute to the risk of early-stage OPSCC (p=0.024). In addition, the T,RP1/T,RP1 diplotype was correlated with better disease-specific survival (T,RP1/T,RP1 vs. other diplotypes, adjusted hazard ratio=0.70, 95% CI: 0.50-0.97).The T, RP1/T, RP1 diplotype of IL-4 was associated with an increased risk but favourable prognosis of OPSCC.
- Subjects :
- Adult
Male
Risk
medicine.medical_specialty
Alcohol Drinking
Genotype
Kaplan-Meier Estimate
Biology
Polymerase Chain Reaction
Gastroenterology
Internal medicine
Odds Ratio
medicine
Humans
General Dentistry
Areca
Interleukin 4
Proportional Hazards Models
Mouth neoplasm
Polymorphism, Genetic
Proportional hazards model
Smoking
Case-control study
Interleukin
Pharyngeal Neoplasms
Cell Biology
General Medicine
Odds ratio
Middle Aged
Prognosis
Otorhinolaryngology
Case-Control Studies
Immunology
Carcinoma, Squamous Cell
Female
Mouth Neoplasms
Pharyngeal Squamous Cell Carcinoma
Interleukin-4
Neoplasm Recurrence, Local
Subjects
Details
- ISSN :
- 00039969
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Archives of Oral Biology
- Accession number :
- edsair.doi.dedup.....c80924c8222b046c1259718dab71ecf0