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Rh-Catalyzed Asymmetric Hydrogenation of 1,2-Dicyanoalkenes
- Source :
- The Journal of Organic Chemistry. 82:680-687
- Publication Year :
- 2016
- Publisher :
- American Chemical Society (ACS), 2016.
-
Abstract
- A highly efficient enantioselective hydrogenation of 1,2-dicyanoalkenes catalyzed by the complex of rhodium and f-spiroPhos has been developed. A series of 1,2-dicyanoalkenes were successfully hydrogenated to the corresponding chiral 1,2-dicyanoalkanes under mild conditions with excellent enantioselectivities (up to 98% ee). This methodology provides efficient access to the asymmetric synthesis of chiral diamines.
Details
- ISSN :
- 15206904 and 00223263
- Volume :
- 82
- Database :
- OpenAIRE
- Journal :
- The Journal of Organic Chemistry
- Accession number :
- edsair.doi.dedup.....c82218cf0a9b5209ea950e8f223f5ca8