Back to Search
Start Over
Prenatal animal contact and gene expression of innate immunity receptors at birth are associated with atopic dermatitis
- Source :
- Journal of Allergy and Clinical Immunology, Journal of Allergy and Clinical Immunology, Elsevier, 2011, 127 (1), pp.179-85, 185.e1. ⟨10.1016/j.jaci.2010.10.010⟩, Journal of Allergy and Clinical Immunology, Elsevier, 2011, 127 (1), pp.179-85, 185.e1. 〈10.1016/j.jaci.2010.10.010〉
- Publication Year :
- 2011
- Publisher :
- HAL CCSD, 2011.
-
Abstract
- International audience; BACKGROUND: Cross-sectional studies have suggested that prenatal farm exposures might protect against allergic disease and increase the expression of receptors of the innate immune system. However, epidemiologic evidence supporting the association with atopic dermatitis remains inconsistent. OBJECTIVE: To study the association between prenatal farm-related exposures and atopic dermatitis in a prospective study. We further analyzed the association between the expression of innate immune genes at birth and atopic dermatitis. METHODS: A total of 1063 children who participated in a birth cohort study, Protection against Allergy-Study in Rural Environments, were included in this study. Doctor diagnosis of atopic dermatitis was reported by the parents from 1 to 2 years of age by questionnaire. Gene expression of Toll-like receptors (TLRs) and CD14 was assessed in cord blood leukocytes by quantitative PCR. RESULTS: Maternal contact with farm animals and cats during pregnancy had a significantly protective effect on atopic dermatitis in the first 2 years of life. The risk of atopic dermatitis was reduced by more than half among children with mothers having contact with 3 or more farm animal species during pregnancy compared with children with mothers without contact (adjusted odds ratio, 0.43; 95% CI, 0.19-0.97). Elevated expression of TLR5 and TLR9 in cord blood was associated with decreased doctor diagnosis of atopic dermatitis. A significant interaction between polymorphism in TLR2 and prenatal cat exposure was observed in atopic dermatitis. CONCLUSION: Maternal contact with farm animals and cats during pregnancy has a protective effect on the development of atopic dermatitis in early life, which is associated with a lower expression of innate immune receptors at birth.
- Subjects :
- Rural Population
MESH : Prenatal Exposure Delayed Effects
Lipopolysaccharide Receptors
Gene Expression
MESH : Genotype
Disease
MESH : Animals, Domestic
MESH : Child, Preschool
MESH : Agriculture
Cohort Studies
MESH: Genotype
0302 clinical medicine
MESH: Pregnancy
MESH: Rural Population
Pregnancy
MESH: Reverse Transcriptase Polymerase Chain Reaction
MESH : Dermatitis, Atopic
Immunology and Allergy
Medicine
MESH : Female
MESH: Animals
MESH: Cohort Studies
2. Zero hunger
0303 health sciences
Reverse Transcriptase Polymerase Chain Reaction
MESH: Antigens, CD14
MESH: Polymorphism, Single Nucleotide
MESH : Polymorphism, Single Nucleotide
Toll-Like Receptors
MESH : Reverse Transcriptase Polymerase Chain Reaction
MESH : Infant
[ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie
Agriculture
Environmental exposure
Atopic dermatitis
MESH : Immunity, Innate
MESH: Infant
3. Good health
Animals, Domestic
Child, Preschool
Prenatal Exposure Delayed Effects
Hay fever
Female
MESH: Immunity, Innate
MESH: Cats
MESH : Cats
MESH: Agriculture
MESH: Toll-Like Receptors
Cohort study
MESH: Gene Expression
Genotype
Immunology
MESH: Environmental Exposure
MESH : Cohort Studies
Polymorphism, Single Nucleotide
Dermatitis, Atopic
MESH: Prenatal Exposure Delayed Effects
03 medical and health sciences
MESH: Dermatitis, Atopic
Animals
Humans
MESH: Animals, Domestic
030304 developmental biology
Asthma
MESH: Humans
business.industry
MESH : Humans
MESH: Child, Preschool
Infant
Odds ratio
Environmental Exposure
medicine.disease
Immunity, Innate
MESH : Gene Expression
MESH : Rural Population
body regions
MESH : Pregnancy
MESH : Antigens, CD14
030228 respiratory system
MESH : Toll-Like Receptors
Cats
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
MESH : Animals
business
MESH : Environmental Exposure
MESH: Female
Subjects
Details
- Language :
- English
- ISSN :
- 00916749
- Database :
- OpenAIRE
- Journal :
- Journal of Allergy and Clinical Immunology, Journal of Allergy and Clinical Immunology, Elsevier, 2011, 127 (1), pp.179-85, 185.e1. ⟨10.1016/j.jaci.2010.10.010⟩, Journal of Allergy and Clinical Immunology, Elsevier, 2011, 127 (1), pp.179-85, 185.e1. 〈10.1016/j.jaci.2010.10.010〉
- Accession number :
- edsair.doi.dedup.....c83d6af237e4241ebe000209ac27e9a6
- Full Text :
- https://doi.org/10.1016/j.jaci.2010.10.010⟩