Oncogenic CagA promotes gastric cancer risk via activating ERK signaling pathways: a nested case-control study

Authors :: Sue K. Park
Hai-Rim Shin
Dong Soo Han
Soung-Hoon Chang
Keun-Young Yoo
Lisa Y. Cho
Yong Sung Kim
Seung Hyun Ma
Kyu Sang Song
Jae Jeong Yang
Kwang-Pil Ko
Bo Youl Choi
Aesun Shin
Daehee Kang
Source :: PLoS ONE, Vol 6, Iss 6, p e21155 (2011), PLoS ONE
Publication Year :: 2011
Publisher :: Public Library of Science (PLoS), 2011.
Abstract: BACKGROUND: CagA cellular interaction via activation of the ERK signaling pathway may be a starting point in the development of gastric cancer. This study aimed to evaluate whether genes involved in ERK downstream signaling pathways activated by CagA are susceptible genetic markers for gastric cancer. METHODS: In the discovery phase, a total of 580 SNPs within +/-5 kbp of 30 candidate genes were genotyped to examine an association with gastric cancer risk in the Korean Multi-center Cancer Cohort (100 incident gastric cancer case-control sets). The most significant SNPs (raw or permutated p value

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