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Neurophysiological responses to unpleasant stimuli (acute electrical stimulations and emotional pictures) are increased in patients with schizophrenia
- Source :
- Scientific Reports, Scientific Reports, 2016, 6 (22542), ⟨10.1038/srep22542⟩, Scientific Reports, Nature Publishing Group, 2016, 6 (22542), ⟨10.1038/srep22542⟩
- Publication Year :
- 2016
- Publisher :
- HAL CCSD, 2016.
-
Abstract
- Patients with schizophrenia have often been described as insensitive to nociceptive signals, but objective evidence is sparse. We address this question by combining subjective behavioral and objective neurochemical and neurophysiological measures. The present study involved 21 stabilized and mildly symptomatic patients with schizophrenia and 21 control subjects. We applied electrical stimulations below the pain threshold and assessed sensations of pain and unpleasantness with rating scales, and Somatosensory Evoked Potentials (SEPs/EEG). We also measured attention, two neurochemical stress indices (ACTH/cortisol), and subjective VEPs/EEG responses to visual emotional stimuli. Our results revealed that, subjectively, patients’ evaluations do not differ from controls. However, the amplitude of EEG evoked potentials was greater in patients than controls as early as 50 ms after electrical stimulations and beyond one second after visual processing of emotional pictures. Such responses could not be linked to the stress induced by the stimulations, since stress hormone levels were stable. Nor was there a difference between patients and controls in respect of attention performance and tactile sensitivity. Taken together, all indices measured in patients in our study were either heightened or equivalent relative to healthy volunteers.
- Subjects :
- Adult
Male
medicine.medical_specialty
Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC]
Emotions
Aucun
Pain
Electroencephalography
Audiology
Article
Visual processing
03 medical and health sciences
0302 clinical medicine
Neurochemical
Evoked Potentials, Somatosensory
Threshold of pain
Medicine
Humans
[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Multidisciplinary
medicine.diagnostic_test
business.industry
Neurophysiology
Middle Aged
medicine.disease
Electric Stimulation
030227 psychiatry
Nociception
Somatosensory evoked potential
Schizophrenia
Female
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
business
030217 neurology & neurosurgery
Stress, Psychological
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Database :
- OpenAIRE
- Journal :
- Scientific Reports, Scientific Reports, 2016, 6 (22542), ⟨10.1038/srep22542⟩, Scientific Reports, Nature Publishing Group, 2016, 6 (22542), ⟨10.1038/srep22542⟩
- Accession number :
- edsair.doi.dedup.....c845d8aaf75e8d06f6b0a6ad184e68aa