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Primary, secondary and compensated male biochemical hypogonadism in people living with HIV (PLWH): relevance of sex hormone-binding globulin (SHBG) measurement and comparison between liquid chromatography-tandem mass spectrometry (LC-MS/MS) and chemiluminescent immunoassay for sex steroids assay
- Source :
- The Aging Male. 25:41-53
- Publication Year :
- 2022
- Publisher :
- Informa UK Limited, 2022.
-
Abstract
- Data about classification of hypogonadism and estrogen deficiency in male people living with HIV (PLWH) are scanty.To investigate the prevalence and characterization of biochemical hypogonadism and relative estrogen deficiency in male PLWH aged50 comparing liquid chromatography-tandem mass spectrometry (LC-MS/MS) with chemiluminescent immunoassay (CI), and combining gonadotropin, sex hormone-binding globulin (SHBG) and serum estradiol (E2) measurements.Prospective, cross-sectional, observational study. Serum total testosterone (TT), E2, gonadotropins, SHBG were measured by CI. TT and E2 were also assessed by LC-MS/MS. Free testosterone (cFT) was calculated by Vermeulen equation.A total of 316 PLWH (45.3 ± 5.3 years) were enrolled. TT and cFT by LC-MS/MS were lower compared to CI (The prevalence of male hypogonadism results underestimated by CI compared to LC-MS/MS in PLWH, both for TT and cFT. SHBG and gonadotropins are essential for detecting T deficiency.
- Subjects :
- Male
HIV
SHBG
hypogonadism
sex steroids
testosterone
Aged
Chromatography, Liquid
Cross-Sectional Studies
Humans
Immunoassay
Prospective Studies
Sex Hormone-Binding Globulin
Tandem Mass Spectrometry
Testosterone
HIV Infections
Hypogonadism
sex steroid
HIV Infection
Cross-Sectional Studie
Chromatography
Liquid
Middle Aged
Prospective Studie
Geriatrics and Gerontology
Human
Subjects
Details
- ISSN :
- 14730790 and 13685538
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- The Aging Male
- Accession number :
- edsair.doi.dedup.....c8478e4755fa7bc3b0a03cb86a3983ee