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Susceptibility for NSAIDs-induced apoptosis correlates to p53 gene status in gastric cancer cells
- Source :
- Cancer investigation. 26(9)
- Publication Year :
- 2008
-
Abstract
- The anti-tumor effect of non-steroidal anti-inflammatory drugs (NSAIDs) remains unclear. Here, we found that the susceptibility for NSAIDs-induced apoptosis might correlate with the status of the p53 gene in gastric cancer cells. Apoptosis in gastric cancer cells expressing wild-type p53 is induced through up-regulation of bax and down-regulation of bcl-2 and that regulation of the bax-bcl-2 heterodimer may be a major target of NSAIDs. As to gastric cancer cells expressing mutant-type p53, other key factors may exist in the NSAIDs' growth inhibition action.
- Subjects :
- Cancer Research
Indomethacin
Down-Regulation
Antineoplastic Agents
Apoptosis
chemistry.chemical_compound
Stomach Neoplasms
Cell Line, Tumor
Medicine
Humans
Gene
bcl-2-Associated X Protein
Aspirin
business.industry
Anti-Inflammatory Agents, Non-Steroidal
General Medicine
digestive system diseases
Up-Regulation
Key factors
Oncology
chemistry
Proto-Oncogene Proteins c-bcl-2
Drug Resistance, Neoplasm
Cancer cell
Mutation
Cancer research
Growth inhibition
Tumor Suppressor Protein p53
business
Dimerization
Subjects
Details
- ISSN :
- 15324192
- Volume :
- 26
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Cancer investigation
- Accession number :
- edsair.doi.dedup.....c84ee545959bd09e26ea6d1c5cc85681