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Effect of Long-term Transfusion on Growth in Children with Sickle Cell Anemia: Results of the Stop Trial

Effect of Long-term Transfusion on Growth in Children with Sickle Cell Anemia: Results of the Stop Trial

Authors :
Winfred C. Wang
Donald Brambilla
Nancy F. Olivieri
Lori Styles
Knashawn H. Morales
Robert J. Adams
Charles D. Scher
Source :
The Journal of Pediatrics. 147:244-247
Publication Year :
2005
Publisher :
Elsevier BV, 2005.

Abstract

Objective To determine whether long-term transfusion improves growth in children with sickle cell anemia. Study design In the Stroke Prevention Trial for Sickle Cell Anemia Study, patients were randomized to receive long-term transfusion (CTX) or standard care (STC). Transfusions were administered every 3 to 5 weeks, and hemoglobin S levels were maintained at 30% pretransfusion for an average of 2 years. Serial height and weight measurements (obtained every 3 months), body mass index (BMI) values, and growth z-scores were analyzed. Results Children in the CTX (n=53) and STC (n=41) groups were similar at baseline. After 24 months, the z-scores for height, weight, and BMI of those receiving CTX had improved significantly, whereas no changes occurred in the STC group. Patients in the CTX group approached normal height-for-age and weight-for-age z-scores. Patients from a large historical control group had significantly lower weight and height growth velocities than patients in the CTX group. Conclusions Patients in the Stroke Prevention Trial for Sickle Cell Anemia Study who received CTX had improved height and weight and BMI over a 2-year period. Higher hemoglobin levels resulting from transfusion may improve growth by lowering energy expenditure. In addition to the prevention of vasoocclusive events, CTX results in significant improvement in the growth of children with sickle cell disease.

Details

ISSN :
00223476
Volume :
147
Database :
OpenAIRE
Journal :
The Journal of Pediatrics
Accession number :
edsair.doi.dedup.....c864d99ff11bf74580f2788e0ee4a9ce
Full Text :
https://doi.org/10.1016/j.jpeds.2005.02.030