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Effect of Long-term Transfusion on Growth in Children with Sickle Cell Anemia: Results of the Stop Trial
Effect of Long-term Transfusion on Growth in Children with Sickle Cell Anemia: Results of the Stop Trial
- Source :
- The Journal of Pediatrics. 147:244-247
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- Objective To determine whether long-term transfusion improves growth in children with sickle cell anemia. Study design In the Stroke Prevention Trial for Sickle Cell Anemia Study, patients were randomized to receive long-term transfusion (CTX) or standard care (STC). Transfusions were administered every 3 to 5 weeks, and hemoglobin S levels were maintained at 30% pretransfusion for an average of 2 years. Serial height and weight measurements (obtained every 3 months), body mass index (BMI) values, and growth z-scores were analyzed. Results Children in the CTX (n=53) and STC (n=41) groups were similar at baseline. After 24 months, the z-scores for height, weight, and BMI of those receiving CTX had improved significantly, whereas no changes occurred in the STC group. Patients in the CTX group approached normal height-for-age and weight-for-age z-scores. Patients from a large historical control group had significantly lower weight and height growth velocities than patients in the CTX group. Conclusions Patients in the Stroke Prevention Trial for Sickle Cell Anemia Study who received CTX had improved height and weight and BMI over a 2-year period. Higher hemoglobin levels resulting from transfusion may improve growth by lowering energy expenditure. In addition to the prevention of vasoocclusive events, CTX results in significant improvement in the growth of children with sickle cell disease.
- Subjects :
- Hemolytic anemia
Pediatrics
medicine.medical_specialty
Blood transfusion
Adolescent
Anemia
medicine.medical_treatment
Anemia, Sickle Cell
Growth
law.invention
Randomized controlled trial
Antisickling Agents
law
medicine
Humans
Hydroxyurea
Blood Transfusion
Child
business.industry
Body Weight
medicine.disease
Body Height
Sickle cell anemia
Stroke
Clinical trial
Hemoglobinopathy
Child, Preschool
Pediatrics, Perinatology and Child Health
Linear Models
business
Body mass index
Subjects
Details
- ISSN :
- 00223476
- Volume :
- 147
- Database :
- OpenAIRE
- Journal :
- The Journal of Pediatrics
- Accession number :
- edsair.doi.dedup.....c864d99ff11bf74580f2788e0ee4a9ce
- Full Text :
- https://doi.org/10.1016/j.jpeds.2005.02.030