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Neutrophil gelatinase‐associated lipocalin: An early biomarker for predicting acute kidney injury and severity in patients with acute pancreatitis
- Source :
- JGH Open: An Open Access Journal of Gastroenterology and Hepatology
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Background and Aim Acute kidney injury (AKI) in severe acute pancreatitis (SAP) has a high mortality rate. Traditionally used serum creatinine is an insensitive biomarker for the early detection of AKI. We aimed to study the role of plasma and urinary neutrophil gelatinase‐associated lipocalin (NGAL) in predicting AKI and a severe course in patients with acute pancreatitis (AP). Methods Consecutive patients of AP who presented within 72 h of symptom onset and age‐ and gender‐matched healthy controls were included. Urinary and serum NGAL levels [enzyme‐linked immunosorbent assay (ELISA)] were evaluated within 24 h of and 72 h after admission and once in controls. Urine and serum NGAL levels were correlated with development of AKI, severity, and outcomes of AP. Results Fifty patients with AP and 30 controls were enrolled. The mean serum and urine NGAL levels in patients on day 1 were significantly higher than the serum and urine NGAL levels in controls (P
- Subjects :
- medicine.medical_specialty
acute pancreatitis
Urinary system
Urine
Lipocalin
Gastroenterology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
medicine
organ failure
Creatinine
Hepatology
business.industry
Mortality rate
creatinine
Acute kidney injury
Original Articles
medicine.disease
neutrophil gelatinase‐associated lipocalin
acute kidney injury
chemistry
030220 oncology & carcinogenesis
Acute pancreatitis
Biomarker (medicine)
Original Article
030211 gastroenterology & hepatology
business
Subjects
Details
- ISSN :
- 23979070
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- JGH Open
- Accession number :
- edsair.doi.dedup.....c86687c0bdbe8e545af7fa5686d3b924