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Hypoxic adaptation of the peptidergic innervation in the rat carotid body
- Source :
- Brain Research. 806:165-174
- Publication Year :
- 1998
- Publisher :
- Elsevier BV, 1998.
-
Abstract
- The abundance of substance P (SP)-, calcitonin gene-related peptide (CGRP)-, vasoactive intestinal polypeptide (VIP)-, and neuropeptide Y (NPY)-immunoreactive nerve fibers in the carotid body was compared between normoxic and chronically hypoxic rats (10% O 2 and 3.0–4.0% CO 2 for 3 months). The immunoreactive fibers appeared as thin processes with many varicosities, and were distributed mainly around the vasculatures. In the normoxic control carotid body, NPY fibers were more numerous than VIP, CGRP, and SP fibers. In the chronically hypoxic rats, the carotid body was enlarged several fold, and the mean absolute number of VIP and NPY fibers was 3.88 and 2.22 times higher than in the normoxic carotid body, respectively, although that of SP and CGRP fibers was not changed. When expressed as density per unit area of the parenchyma, the density of SP and CGRP fibers in the chronically hypoxic carotid body decreased significantly to under 50%, the density of VIP fibers increased significantly 1.80 times, and the density of NPY fibers were unchanged. Immunoreactivity for four neuropeptides was not found in the glomus cells of normoxic or chronically hypoxic carotid bodies. These results suggest that altered peptidergic innervation of the chronically hypoxic carotid body is one feature of hypoxic adaptation. Because these neuropeptides are vasoactive in nature, altered carotid body circulation may contribute to modulation of the chemosensory mechanisms by chronic hypoxia.
- Subjects :
- medicine.medical_specialty
Vasoactive intestinal peptide
Neuropeptide
Substance P
Calcitonin gene-related peptide
Biology
chemistry.chemical_compound
Nerve Fibers
Glomus cell
Reference Values
Internal medicine
medicine
Animals
Hypoxia
Molecular Biology
Carotid Body
General Neuroscience
Neuropeptides
Hypoxia (medical)
Neuropeptide Y receptor
Adaptation, Physiological
Immunohistochemistry
Rats
medicine.anatomical_structure
Endocrinology
chemistry
Chronic Disease
Carotid body
Neurology (clinical)
medicine.symptom
Developmental Biology
Subjects
Details
- ISSN :
- 00068993
- Volume :
- 806
- Database :
- OpenAIRE
- Journal :
- Brain Research
- Accession number :
- edsair.doi.dedup.....c87994e9086034a94f33d9ef45b08ae7