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Low Ankle-Brachial Index Associated With Rise in Creatinine Level Over Time
Low Ankle-Brachial Index Associated With Rise in Creatinine Level Over Time
- Source :
- Archives of Internal Medicine. 165:1481
- Publication Year :
- 2005
- Publisher :
- American Medical Association (AMA), 2005.
-
Abstract
- Background: A low ankle-brachial index (ABI) predicts risk of cardiovascular death, myocardial infarction, peripheral arterial disease events, and stroke. However, it is unknown whether a low ABI also predicts a decline in renal function. Methods:WeexaminedtheassociationbetweenABIand changeinserumcreatininelevelovertimeamong13655 participants in the Atherosclerosis Risk in Communities (ARIC) study who underwent serum creatinine and ABI measurement at baseline and also underwent serum creatinine measurement 3 years later at the second study visit. The study outcome was a 50% rise in serum creatinine level from baseline to the second study visit. Results: Overall, 0.48% of participants with an ABI of 1 or higher, 0.9% of participants with an ABI between 0.9and0.99,and2.16%ofparticipantswithanABIlower than 0.9 experienced a 50% or greater increase in serum creatininelevel.Inmultivariateanalysis,participantswith an ABI lower than0.9 were still more thantwice as likely as those in the referent category (ABI 1) to experience anincreaseinserumcreatininelevel(oddsratio2.5;95% confidence interval, 1.1-5.7) (P=.04), and a linear trend in the incidence of worsening renal function was noted across ABI categories (P=.02). Analyses excluding participants with renal insufficiency, diabetes, and hypertension at baseline all produced similar results. Conclusion: In addition to known associations of the ABI with stroke, myocardial infarction, peripheral arterial disease events, and cardiovascular death, a low ABI also predicts an increase in serum creatinine level over time. Arch Intern Med. 2005;165:1481-1485
- Subjects :
- Male
medicine.medical_specialty
Brachial Artery
Arteriosclerosis
Renal function
Blood Pressure
Serum Creatinine Measurement
urologic and male genital diseases
chemistry.chemical_compound
Predictive Value of Tests
Risk Factors
Internal medicine
Odds Ratio
Internal Medicine
medicine
Humans
Popliteal Artery
Prospective Studies
cardiovascular diseases
Myocardial infarction
Risk factor
Prospective cohort study
Stroke
Creatinine
business.industry
Middle Aged
Prognosis
medicine.disease
body regions
Blood pressure
chemistry
cardiovascular system
Physical therapy
Cardiology
Female
Ankle
business
human activities
Biomarkers
Follow-Up Studies
Subjects
Details
- ISSN :
- 00039926
- Volume :
- 165
- Database :
- OpenAIRE
- Journal :
- Archives of Internal Medicine
- Accession number :
- edsair.doi.dedup.....c887e142c57b92308cf6dd3b530171de
- Full Text :
- https://doi.org/10.1001/archinte.165.13.1481