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Validation of a novel index to assess insulin resistance of adipose tissue lipolytic activity in obese subjects
- Source :
- Journal of Lipid Research, Vol 53, Iss 2, Pp 321-324 (2012)
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- Insulin resistance in adipose tissue increases the release of free fatty acids into the circulation, which likely contributes to impaired insulin action in liver and skeletal muscle associated with obesity. However, reliable assessment of adipose tissue insulin resistance requires performing a hyperinsulinemic-euglycemic clamp procedure in conjunction with a fatty acid tracer infusion to determine insulin-mediated suppression of lipolytic rate. We developed a simpler method for evaluating adipose tissue insulin resistance in vivo, determined as the product of palmitate rate of appearance into the bloodstream and plasma insulin concentration during basal conditions. We validated our Adipose Tissue Insulin Resistance Index (ATIRI) by comparison with an assessment of adipose tissue insulin resistance determined by using the hyperinsulinemic-euglycemic clamp procedure in conjunction with a palmitate tracer infusion in 47 obese nondiabetic subjects (body mass index: 40.1 ± 9.3 kg/m(2)). We found the ATIRI correlated closely with adipose tissue insulin resistance assessed during the clamp procedure (r =-0.854, P < 0.001). These results demonstrate that the ATIRI provides a reliable index of adipose tissue insulin resistance in obese subjects.
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.medical_treatment
Palmitates
Adipose tissue
QD415-436
White adipose tissue
Biology
Biochemistry
adipose tissue insulin sensitivity
hyperinsulinemic-euglycemic clamp
Body Mass Index
palmitate rate of appearance
Endocrinology
Insulin resistance
Internal medicine
Methods
medicine
Humans
Obesity
chemistry.chemical_classification
fatty acid kinetics
Insulin
Fatty acid
Skeletal muscle
Settore MED/13 - ENDOCRINOLOGIA
Cell Biology
Middle Aged
Glucose clamp technique
medicine.disease
stable isotope tracers
medicine.anatomical_structure
suppression of lipolysis
Adipose Tissue
chemistry
Basal (medicine)
Glucose Clamp Technique
Female
Insulin Resistance
Human
Subjects
Details
- ISSN :
- 00222275
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- Journal of Lipid Research
- Accession number :
- edsair.doi.dedup.....c89212382dbb4fc9e11194634b94c4a6