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Subacute Sclerosing Panencephalitis
- Source :
- Archives of Neurology. 23:97
- Publication Year :
- 1970
- Publisher :
- American Medical Association (AMA), 1970.
-
Abstract
- ALTHOUGH a viral etiology for subacute sclerosing panencephalitis (SSPE) was first postulated by Dawson 1 in 1933, the isolation of measles-like viruses from brain cell cultures established from biopsies of SSPE patients has been a recent accomplishment. 2-4 The SSPE agents, either present in brain biopsies of patients or isolated from their brain tissue maintained in culture, have been found to be pathogenic for ferrets, 5,6 with encephalitis becoming manifest after a prolonged incubation period. Because of the difficulties involved in handling ferrets and the excessive costs of their maintenance, a search became necessary for another experimental host—an animal at least as susceptible as the ferret to SSPE infection, but easier to handle and less costly to maintain. The present study shows that the hamster meets these criteria; intracerebral inoculation of hamsters with human brain culture cells carrying the SSPE agents, or with cell-free SSPE virus, produces encephalitis. Materials and
- Subjects :
- Biopsy
Carnivora
Hamster
Biology
Brain Cell
Subacute sclerosing panencephalitis
Arts and Humanities (miscellaneous)
Cricetinae
Culture Techniques
medicine
Animals
Humans
SSPE Virus
Prolonged incubation
Cell-Free System
fungi
Brain
virus diseases
Diffuse Cerebral Sclerosis of Schilder
Human brain
medicine.disease
Virology
nervous system diseases
Intracerebral inoculation
Disease Models, Animal
Microscopy, Electron
medicine.anatomical_structure
Animals, Newborn
Measles virus
Viruses
Immunology
Neurology (clinical)
Encephalitis
Subjects
Details
- ISSN :
- 00039942
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Archives of Neurology
- Accession number :
- edsair.doi.dedup.....c899230fc3f6916d422579e57dc4b4d3