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Profile of GenMark’s ePlex® blood culture identification fungal pathogen panel

Authors :
Danièle Maubon
Muriel Cornet
Cécile Garnaud
Céline Dard
Thérapeutique Recombinante Expérimentale (TIMC-IMAG-TheREx)
Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG)
Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])
Laboratoire de parasitologie-mycologie
CHU Grenoble
Source :
Expert Review of Molecular Diagnostics, Expert Review of Molecular Diagnostics, Expert Reviews (formerly Future Drugs), 2017, pp.1-14. ⟨10.1080/14737159.2018.1420476⟩
Publication Year :
2017
Publisher :
Informa UK Limited, 2017.

Abstract

International audience; Fungemia presents high morbi-mortality and thus rapid microbiological diagnosis may contribute to appropriate patient management. In the last decade, kits based on molecular technologies have become available and health care institutes are increasingly facing critical investment choices. Although all these tools aim to achieve rapid fungal detection and species identification, they display different inherent characteristics. Areas covered: Considering technologies allowing detection and identification of fungal species in a sepsis context, the market proposes either tests on positive blood culture or tests on patient's whole blood. In this review, the authors describe and compare the ePlex® Blood Culture Identification Fungal Pathogen (BCID-FP) test, a fully automated one-step single-use cartridge assay that has been designed to detect identify frequent or rare but emerging, fungal species, from positive blood culture. A comparison with the competing kits is provided. Expert commentaries: The ePlex BCID-FP test provides a diversified and rather relevant panel. Its easy-to-use cartridges allow flexible use around the clock. Nevertheless, prospective clinical studies assessing the time-to-result benefit on antifungal stewardship and on hospital length of stay are not available yet. New tools aim to benefit clinicians and patients, but they should be accompanied by supervision of result interpretation and adaptation of antifungal stewardship.

Details

ISSN :
17448352 and 14737159
Volume :
18
Database :
OpenAIRE
Journal :
Expert Review of Molecular Diagnostics
Accession number :
edsair.doi.dedup.....c8a546359c39a84333bba45b3342ecf9
Full Text :
https://doi.org/10.1080/14737159.2018.1420476