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Emergence of recombinant Mayaro virus strains from the Amazon basin
- Source :
- Scientific Reports, Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
- Publication Year :
- 2017
- Publisher :
- Nature Publishing Group UK, 2017.
-
Abstract
- Mayaro virus (MAYV), causative agent of Mayaro Fever, is an arbovirus transmitted by Haemagogus mosquitoes. Despite recent attention due to the identification of several cases in South and Central America and the Caribbean, limited information on MAYV evolution and epidemiology exists and represents a barrier to prevention of further spread. We present a thorough spatiotemporal evolutionary study of MAYV full-genome sequences collected over the last sixty years within South America and Haiti, revealing recent recombination events and adaptation to a broad host and vector range, including Aedes mosquito species. We employed a Bayesian phylogeography approach to characterize the emergence of recombinants in Brazil and Haiti and report evidence in favor of the putative role of human mobility in facilitating recombination among MAYV strains from geographically distinct regions. Spatiotemporal characteristics of recombination events and the emergence of this previously neglected virus in Haiti, a known hub for pathogen spread to the Americas, warrants close monitoring of MAYV infection in the immediate future.
- Subjects :
- 0301 basic medicine
Time Factors
Genotype
Range (biology)
Science
Alphavirus
Genome, Viral
Arbovirus
Virus
Article
03 medical and health sciences
Phylogenetics
Aedes
medicine
Animals
Humans
Haemagogus
Selection, Genetic
Codon
Phylogeny
Recombination, Genetic
Likelihood Functions
Multidisciplinary
biology
Ecology
Bayes Theorem
medicine.disease
biology.organism_classification
Phylogeography
030104 developmental biology
Evolutionary biology
Genetic Code
Vector (epidemiology)
Medicine
Brazil
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....c8ab722dba0562d3c2eceac4e1867d49