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Endoscopic ultrasound‐guided ablation of branch‐duct intraductal papillary mucinous neoplasms: Feasibility and safety tests using porcine gallbladders
- Source :
- Digestive Endoscopy. 28:599-606
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Background and Aim Radiofrequency ablation (RFA) and ethanol ablation are accepted methods of tissue destruction for treating cystic tumors. The aim of the present study was to evaluate the feasibility, efficacy, and safety of endoscopic ultrasound (EUS)-guided ablation using normal porcine gallbladders as a substitute model for branch-duct intraductal papillary mucinous neoplasms (BD-IPMN). Methods Six adult mini pigs were included in this prospective study. EUS-guided RFA with or without ethanol ablation of the gallbladder was carried out using a prototype 18-gauge endoscopic RFA electrode, and RFA and ethanol ablation were done in a single session. Outcomes were assessed in terms of macroscopic and microscopic evaluations of the treated gallbladders. Results The prototype RFA electrode was used for ablation of the mucosa, aspiration of the internal contents of the gallbladder, and ethanol injection. RFA plus ethanol lavage resulted in a greater mean percentage of denuded gallbladder mucosa (97.5%) than RFA alone (55.8%). Effects of ablation extending to the cystic duct and partially denuded cystic duct mucosae were detected in five of the six pigs. There were no major procedure-related adverse events. Conclusions EUS-guided ablation of the gallbladder mucosa was feasible and effective in the porcine model. Additional studies will be required to fully assess the risk of procedure-related damage to the main pancreatic duct before using this technique in a clinical setting.
- Subjects :
- Endoscopic ultrasound
medicine.medical_specialty
Swine
Ablation Techniques
Radiofrequency ablation
medicine.medical_treatment
Catheter ablation
Endosonography
law.invention
03 medical and health sciences
0302 clinical medicine
law
medicine
Animals
Radiology, Nuclear Medicine and imaging
Pancreatic duct
medicine.diagnostic_test
business.industry
Gallbladder
Gastroenterology
Ablation
Adenocarcinoma, Mucinous
Pancreatic Neoplasms
Disease Models, Animal
surgical procedures, operative
medicine.anatomical_structure
030220 oncology & carcinogenesis
Catheter Ablation
Feasibility Studies
Cystic duct
030211 gastroenterology & hepatology
Radiology
business
Carcinoma, Pancreatic Ductal
Subjects
Details
- ISSN :
- 14431661 and 09155635
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Digestive Endoscopy
- Accession number :
- edsair.doi.dedup.....c8b750416e716edbd9d74f8fb17766e5