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The association of indoxyl sulfate with fibroblast growth factor‐23 in cats with chronic kidney disease
- Source :
- Journal of Veterinary Internal Medicine
- Publication Year :
- 2019
- Publisher :
- John Wiley & Sons, Inc., 2019.
-
Abstract
- Background Indoxyl sulfate (IS) has been reported not only to increase with the severity of impaired renal function, but also possibly to be a factor associated with bone abnormalities linked to fibroblast growth factor‐23 (FGF‐23) in humans with chronic kidney disease (CKD). It is not yet known whether this correlation between IS and FGF‐23 holds true for cats with CKD. Hypothesis Accumulation of IS is related to FGF‐23 secretion in cats with CKD. Animals Twenty clinically healthy cats and 73 cats with CKD cases were evaluated retrospectively. Methods The concentrations of IS and FGF‐23 in plasma were determined by high‐performance liquid chromatography and ELISA, respectively. Progression was defined as an increment of 0.5 mg/dL of serum creatinine concentration within 3 months. Results Plasma IS and FGF‐23 concentrations were significantly increased concurrently with decreasing renal function. Higher concentration of FGF‐23 was significantly associated with higher concentration of IS after adjusting for various confounding factors including creatinine and phosphate. Furthermore, the correlation between IS and phosphate was higher than that between FGF‐23 and phosphate. When the renal progression group was compared with the non‐progression group, both IS and FGF‐23 were found to be significantly increased (P 0.9. Conclusions and Clinical Importance Both FGF‐23 and IS are associated with phosphate metabolism and CKD progression.
- Subjects :
- Fibroblast growth factor 23
Male
medicine.medical_specialty
040301 veterinary sciences
uremic toxin
Renal function
Enzyme-Linked Immunosorbent Assay
Standard Article
030204 cardiovascular system & hematology
feline renal diseases
phosphate regulator
Cat Diseases
Severity of Illness Index
0403 veterinary science
azotemia
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
medicine
Nephrology/Urology
Animals
Renal Insufficiency, Chronic
Chromatography, High Pressure Liquid
Retrospective Studies
Creatinine
CATS
General Veterinary
business.industry
Confounding
04 agricultural and veterinary sciences
medicine.disease
Phosphate
Standard Articles
Fibroblast Growth Factors
Fibroblast Growth Factor-23
Endocrinology
chemistry
Case-Control Studies
Cats
Disease Progression
Female
Azotemia
SMALL ANIMAL
progression
business
Indican
Kidney disease
Subjects
Details
- Language :
- English
- ISSN :
- 19391676 and 08916640
- Volume :
- 33
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of Veterinary Internal Medicine
- Accession number :
- edsair.doi.dedup.....c8bdcb8bd9697d5a7bf41b9200e23289