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Apremilast as a target therapy for nail psoriasis: a real-life observational study proving its efficacy in restoring the nail unit
- Publication Year :
- 2020
- Publisher :
- Taylor and Francis Ltd, 2020.
-
Abstract
- Psoriasis, Psoriatic Arthritis and Nail psoriasis are chronic diseases that share a common underlying etiology of immunity dysregulation, enhanced activation of inflammatory pathways and remitting-relapsing course. Although nails represent a small percentage of the body surface involvement of this site can lead to impaired quality of life, severe discomfort and even result in permanent disability. Current therapeutic options for nail psoriasis include a variety of topical and systemic treatments although they are often reported as unsatisfactory from patients either due to their poor effectiveness or disturbing side effects. Recently small molecule drugs such as the PDE4 inhibitors were introduced in clinical practice and specifically apremilast has shown to be an effective new treatment option for psoriasis and psoriatic arthritis. Considering either the specific mechanism of action of apremilast, we performed a real-life observational study of 24 weeks assessing apremilast role in nail psoriasis.Patients received apremilast 30mg bid, orally. Safety and efficacy were assessed at weeks 0, 4, 8, 12 and 24 using Dermatologic Life Quality Index (DLQI) and Nail Area Psoriasis Severity Index (NAPSI). At T0 we took a nail sample to investigate the presence of onychomycosis. Culture tests were performed in all the patients to search for fungi.We recruited a total of 15 patients with nail psoriasis. The analysis of variance (one-way ANOVA) showed the following results: DLQI (F.15.7;Apremilast showed fast and sustained improvement of nail psoriasis over time and a complete resolution of life quality impairment due to the disease.
- Subjects :
- target-therapy
medicine.medical_specialty
Nail psoriasis
apremilast
pde4 inhibitor
Dermatology
Settore MED/04
Severity of Illness Index
030207 dermatology & venereal diseases
03 medical and health sciences
Psoriatic arthritis
Nail Diseases
difficult-to-treat area
0302 clinical medicine
Psoriasis
medicine
Humans
Target therapy
030203 arthritis & rheumatology
integumentary system
business.industry
medicine.disease
Thalidomide
medicine.anatomical_structure
Treatment Outcome
Nails
Etiology
Nail (anatomy)
Quality of Life
Observational study
Apremilast
business
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....c8c7b8ce7775bf9f148711005e92b3e9