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Learning-induced LTP in neocortex
Learning-induced LTP in neocortex
- Source :
- Science (New York, N.Y.). 290(5491)
- Publication Year :
- 2000
-
Abstract
- The hypothesis that learning occurs through long-term potentiation (LTP)– and long-term depression (LTD)–like mechanisms is widely held but unproven. This hypothesis makes three assumptions: Synapses are modifiable, they modify with learning, and they strengthen through an LTP-like mechanism. We previously established the ability for synaptic modification and a synaptic strengthening with motor skill learning in horizontal connections of the rat motor cortex (MI). Here we investigated whether learning strengthened these connections through LTP. We demonstrated that synapses in the trained MI were near the ceiling of their modification range, compared with the untrained MI, but the range of synaptic modification was not affected by learning. In the trained MI, LTP was markedly reduced and LTD was enhanced. These results are consistent with the use of LTP to strengthen synapses during learning.
- Subjects :
- education
Long-Term Potentiation
Models, Neurological
Neurotransmission
Synaptic Transmission
Rats, Sprague-Dawley
Neuroplasticity
medicine
Animals
Learning
Motor skill
Multidisciplinary
Neocortex
Neuronal Plasticity
musculoskeletal, neural, and ocular physiology
Motor Cortex
Long-term potentiation
Electric Stimulation
Rats
Sprague dawley
medicine.anatomical_structure
nervous system
Motor Skills
Synapses
Female
Motor learning
Psychology
Neuroscience
Motor cortex
Subjects
Details
- ISSN :
- 00368075
- Volume :
- 290
- Issue :
- 5491
- Database :
- OpenAIRE
- Journal :
- Science (New York, N.Y.)
- Accession number :
- edsair.doi.dedup.....c8cc78e051031724f96a3b85d20abb00