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T1, diffusion tensor, and quantitative magnetization transfer imaging of the hippocampus in an Alzheimer's disease mouse model
- Source :
- Magnetic Resonance Imaging. 50:26-37
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Alzheimer’s disease (AD) pathology causes microstructural changes in the brain. These changes, if quantified with magnetic resonance imaging (MRI), could be studied for use as an early biomarker for AD. The aim of our study was to determine if T(1) relaxation, diffusion tensor imaging (DTI), and quantitative magnetization transfer imaging (qMTI) metrics could reveal changes within the hippocampus and surrounding white matter structures in ex vivo transgenic mouse brains overexpressing human amyloid precursor protein with the Swedish mutation. Delineation of hippocampal cell layers using DTI color maps allows more detailed analysis of T(1)-weighted imaging, DTI, and qMTI metrics, compared with segmentation of gross anatomy based on relaxation images, and with analysis of DTI or qMTI metrics alone. These alterations are observed in the absence of robust intracellular Aβ accumulation or plaque deposition as revealed by histology. This work demonstrates that multiparametric quantitative MRI methods are useful for characterizing changes within the hippocampal substructures and surrounding white matter tracts of mouse models of AD.
- Subjects :
- Male
Genetically modified mouse
Biomedical Engineering
Biophysics
Hippocampus
Mice, Transgenic
Hippocampal formation
Article
030218 nuclear medicine & medical imaging
White matter
Mice
03 medical and health sciences
0302 clinical medicine
Nuclear magnetic resonance
Alzheimer Disease
Image Processing, Computer-Assisted
medicine
Amyloid precursor protein
Animals
Humans
Radiology, Nuclear Medicine and imaging
medicine.diagnostic_test
biology
Chemistry
Magnetic resonance imaging
Biomarker (cell)
Disease Models, Animal
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging
medicine.anatomical_structure
biology.protein
030217 neurology & neurosurgery
Diffusion MRI
Subjects
Details
- ISSN :
- 0730725X
- Volume :
- 50
- Database :
- OpenAIRE
- Journal :
- Magnetic Resonance Imaging
- Accession number :
- edsair.doi.dedup.....c8d519adc59dc56820d2c45f17701a3a