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Nasal Cytology as a Diagnostic Tool for Local Allergic Rhinitis
- Source :
- American Journal of Rhinology & Allergy. 33:540-544
- Publication Year :
- 2019
- Publisher :
- SAGE Publications, 2019.
-
Abstract
- Background Local allergic rhinitis (LAR) is characterized by chronic rhinitis with localized nasal allergic response to allergens in the absence of systemic immunoglobulin (IgE)-mediated disease assessed by skin prick test (SPT) or specific serum IgE level. Nasal provocation test (NPT) is the gold standard for the diagnosis of LAR. Nasal eosinophilia is a known inflammatory marker in allergic rhinitis. We hypothesized that nasal eosinophilia can be used as a screening tool for LAR. Objective To determine the applicability of nasal eosinophilia as a diagnostic tool for LAR. Methods Forty-eight perennial nonallergic rhinitis (NAR) patients with SPT negative were recruited. Nasal cytology analysis was performed. NPTs with 3 allergens (mixed mites, mixed cockroaches, and Bermuda grass) were performed to diagnose LAR. Nasal symptoms combined with nasal patency were used to determine the results of NPT. The sensitivity, specificity, positive predictive value, and negative predictive value of nasal eosinophilia as a diagnostic tool of LAR were calculated. Results LAR was diagnosed in 41.6% of the NAR patients. Nasal eosinophilia was found in 58% of the NAR patients. The sensitivity of nasal eosinophilia for diagnosing LAR was 80%, the specificity was 57.14%, the positive predictive value was 57.14%, and the negative predictive value was 80%. The most common allergen of LAR was mixed mites. Conclusion Nasal eosinophilia on nasal cytology was a good screening tool for diagnosing LAR because of its high sensitivity and simplicity of the procedure. Unfortunately, the low specificity of nasal eosinophilia makes the NPT necessary for confirmation of LAR.
- Subjects :
- Adult
Male
Nasal Provocation Tests
medicine.medical_treatment
medicine.disease_cause
Immunoglobulin E
Sensitivity and Specificity
Nasal provocation test
Diagnosis, Differential
Young Adult
03 medical and health sciences
0302 clinical medicine
Nonallergic rhinitis
Eosinophilia
otorhinolaryngologic diseases
medicine
Humans
Immunology and Allergy
030223 otorhinolaryngology
Aged
Rhinitis
biology
business.industry
Chronic rhinitis
General Medicine
Perennial rhinitis
Middle Aged
respiratory system
medicine.disease
Rhinitis, Allergic
Eosinophils
Nasal Mucosa
030228 respiratory system
Otorhinolaryngology
Nasal cytology
Chronic Disease
Allergic response
Immunology
biology.protein
Female
Antibody
business
Subjects
Details
- ISSN :
- 19458932 and 19458924
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- American Journal of Rhinology & Allergy
- Accession number :
- edsair.doi.dedup.....c8d7dec00774b1b6bd6dcbd360c0eec3