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Lipid metabolism and lipid signals in aging and longevity
- Source :
- Dev Cell
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Lipids play crucial roles in regulating aging and longevity. In the past few decades, a series of genetic pathways have been discovered to regulate lifespan in model organisms. Interestingly, many of these regulatory pathways are linked to lipid metabolism and lipid signaling. Lipid metabolic enzymes undergo significant changes during aging and are regulated by different longevity pathways. Lipids also actively modulate lifespan and health span as signaling molecules. In this review, we summarize recent insights into the roles of lipid metabolism and lipid signaling in aging and discuss lipid-related interventions in promoting longevity.
- Subjects :
- Cell signaling
Lipoproteins
media_common.quotation_subject
Longevity
ved/biology.organism_classification_rank.species
Receptors, Cell Surface
Biology
Genetic pathways
Article
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Animals
Humans
Model organism
Molecular Biology
030304 developmental biology
media_common
Health span
0303 health sciences
ved/biology
Lipid metabolism
Cell Biology
Lipid signaling
Lipid Metabolism
Lipids
Cell biology
Metabolic enzymes
lipids (amino acids, peptides, and proteins)
030217 neurology & neurosurgery
Signal Transduction
Developmental Biology
Subjects
Details
- ISSN :
- 15345807
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Developmental Cell
- Accession number :
- edsair.doi.dedup.....c8db45fc1626aac0d06b45421bc83a5f