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T-Helper 17 Cells Are Associated With Pathology in Human Schistosomiasis
- Publication Year :
- 2013
-
Abstract
- Background. Schistosome infections are often clinically silent, but some individuals develop severe pathological reactions. In several disease processes, T-helper 17 (Th17) cells have been linked to tissue injuries, while regulatory T cells (Tregs) are thought to downmodulate inflammatory reactions. We assessed whether bladder pathology in human Schistosoma haematobium infection is related to the balance of Th17 cells and Tregs. We used a murine model of Schistosoma mansoni infection to further investigate whether the peripheral profiles reflected ongoing events in tissues. Methods. We characterized T-helper cell subsets in the peripheral blood of children residing in a S. haematobium- endemic area and in the peripheral blood, spleen, and hepatic granulomas of S. mansoni-infected highpathology CBA mice and low-pathology C57BL/6 mice. Results. S. haematobium-infected children with bladder pathology had a significantly higher percentage of Th17 cells than those without pathology. Moreover, the Th17/Treg ratios were significantly higher in infected children with pathology, compared with infected children without pathology. Percentages of interleukin 17-producing cells were significantly higher in spleen and granulomas of CBA mice, compared with C57BL/6 mice. This difference was also reflected in the peripheral blood. Conclusions. This is the first study to indicate that Th17 cells may be involved in the pathogenesis of human schistosomiasis.
- Subjects :
- Male
Pathology
Snails
Pathogenesis
T-Lymphocytes, Regulatory
Mice
Schistosomiasis haematobia
Immunology and Allergy
Schistosomiasis
Child
Children
Schistosoma haematobium
Granuloma
Interleukin-17
Interleukin
Africa, East
Helminthic diseases
hemic and immune systems
Schistosoma mansoni
Middle Aged
Senegal
Infectious Diseases
medicine.anatomical_structure
Child, Preschool
Cytokines
Female
Interleukin 17
Adult
medicine.medical_specialty
Adolescent
Bladder
Characterization
Urinary Bladder
Peripheral blood
Spleen
chemical and pharmacologic phenomena
Biology
Host-Parasite Interactions
T helper cells
Major Articles and Brief Reports
Young Adult
parasitic diseases
medicine
Animals
Humans
Th17 cells
biology.organism_classification
medicine.disease
Schistosomiasis mansoni
Mice, Inbred C57BL
Immunology
Mice, Inbred CBA
pathology
Granulocytes
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....c8e8cd56e49d93880e3eb177ad319867