Back to Search
Start Over
Synthesis and characterization of some metal complexes of a proton transfer salt, and their inhibition studies on carbonic anhydrase isozymes and the evaluation of the results by statistical analysis
- Publication Year :
- 2014
- Publisher :
- Informa Healthcare, 2014.
-
Abstract
- WOS: 000342056900013<br />PubMed ID: 24148087<br />A novel proton transfer compound (HMeOABT) (+) (HDPC)(-) (1) and its Fe(III), Co(II), Ni(II) and Cu(II) complexes (2-5) have been prepared and characterized by spectroscopic techniques. Complex 4 has distorted octahedral conformation revealed by single crystal X-ray diffraction method. Structures of the other complexes might be proposed as octahedral according to experimental data. All compounds were also evaluated for their in vitro inhibition effects on hCA I and II for their hydratase and esterase activities. Although there is no inhibition for hydratase activities, all compounds have inhibited the esterase activities of hCA I and II. Data have been analyzed by using a one-way analysis of variance. The comparison of the inhibition studies of 1-5 to parent compounds indicates that 1-5 have superior inhibitory effects. The inhibition effects of 2-5 are also compared to inhibitory properties of the metal complexes of MeOABT and H2DPC, revealing an improved transfection profile.<br />Dumlupinar University Research Fund [2012/16]<br />The authors acknowledge the support provided by Dumlupinar University Research Fund (grant No. 2012/16). The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.
- Subjects :
- Models, Molecular
Carbonic Anhydrase I
Stereochemistry
Salt (chemistry)
2,6-pyridinedicarboxylic acid
Esterase
Isozyme
Carbonic Anhydrase II
Proton transfer
Metal
Structure-Activity Relationship
Carbonic anhydrase
Metals, Heavy
Drug Discovery
Organometallic Compounds
Humans
Benzothiazoles
Carbonic Anhydrase Inhibitors
Picolinic Acids
Inhibition
Pharmacology
chemistry.chemical_classification
Models, Statistical
biology
Dose-Response Relationship, Drug
Molecular Structure
2-Amino-6-methoxybenzothiazole
General Medicine
In vitro
Isoenzymes
Octahedron
chemistry
visual_art
visual_art.visual_art_medium
biology.protein
Salts
Protons
Single crystal
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....c8eabd5eb8d044c0699d8cc2dcbd8c2a