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Type 1 insulin-like growth factor receptor monoclonal antibody (HX-1162) treatment for liver cancer
- Source :
- OncoTargets and therapy
- Publication Year :
- 2013
- Publisher :
- Informa UK Limited, 2013.
-
Abstract
- Xue-Hui Chen, Zhi-Qiang Li, Hua Peng, Su-Mei Jin, Hui-Qing Fu, Tie-Chui Zhu, Xiao-Gang WengThe First Affiliated Hospital of Xinxiang Medical University, Weihui, People's Republic of ChinaAbstract: One of the most important molecules mediating the proliferation, growth, and metastasis of cancer cells is insulin-like growth factor (IGF), with its receptor IGF-R1. Here, we describe the potential of an IGF-1R monoclonal antibody, HX-1162, on liver cancer apoptosis in vitro and in vivo. We found that HX-1162 could induce the apoptosis of cultured liver cancer cells. Additionally, HX-1162 treatment inhibited the tumor growth after cancer cell grafting and enhanced the cell apoptosis inside the tumor tissue. We conclude that IGF-R1 targeting therapy provides a new avenue toward treating liver cancer.Keywords: IGF, IGF-R1, apoptosis, hepatocellular carcinoma
- Subjects :
- business.industry
medicine.drug_class
Growth factor
medicine.medical_treatment
apoptosis
hepatocellular carcinoma
Insulin-Like Growth Factor Receptor
medicine.disease
Monoclonal antibody
OncoTargets and Therapy
Metastasis
Oncology
Apoptosis
Cancer cell
Immunology
medicine
Cancer research
Pharmacology (medical)
IGF
Liver cancer
business
Receptor
IGF-1R
Original Research
Subjects
Details
- ISSN :
- 11786930
- Database :
- OpenAIRE
- Journal :
- OncoTargets and Therapy
- Accession number :
- edsair.doi.dedup.....c948fc8481b7f5ae76d44edcc1d46ade