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Variant in the sequence of the LINGO1 gene confers risk of essential tremor
- Source :
- Nature Genetics. 41:277-279
- Publication Year :
- 2009
- Publisher :
- Springer Science and Business Media LLC, 2009.
-
Abstract
- We identified a marker in LINGO1 showing genome-wide significant association (P = 1.2 × 10−9, odds ratio = 1.55) with essential tremor. LINGO1 has potent, negative regulatory influences on neuronal survival and is also important in regulating both central-nervous-system axon regeneration and oligodendrocyte maturation. An increase in the number of fusiform swellings of Purkinje cell axons in LINGO1 knockout models highlights the potential role of LINGO1 in essential tremor pathophysiology.
- Subjects :
- Essential Tremor
Population
Iceland
Nerve Tissue Proteins
Genome-wide association study
Biology
Polymorphism, Single Nucleotide
Linkage Disequilibrium
Article
Mice
Gene Frequency
Risk Factors
Germany
Genetics
medicine
Animals
Humans
Genetic Predisposition to Disease
Axon
education
Gene
LINGO1
Mice, Knockout
education.field_of_study
Essential tremor
Regeneration (biology)
Membrane Proteins
medicine.disease
United States
Oligodendrocyte
Cell biology
Genetics, Population
medicine.anatomical_structure
nervous system
Austria
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 15461718 and 10614036
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Nature Genetics
- Accession number :
- edsair.doi.dedup.....c94958f05d0b1d6da6bcbf56237c7627