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Reactive astrocyte nomenclature, definitions, and future directions
- Source :
- Nature neuroscience 24(3), 312-325 (2021). doi:10.1038/s41593-020-00783-4, Escartin, C, Galea, E, Lakatos, A, O'Callaghan, J P, Petzold, G C, Serrano-Pozo, A, Steinhauser, C, Volterra, A, Carmignoto, G, Agarwal, A, Allen, N J, Araque, A, Barbeito, L, Barzilai, A, Bergles, D E, Bonvento, G, Butt, A M, Chen, W-T, Cohen-Salmon, M, Cunningham, C, Deneen, B, De Strooper, B, Diaz-Castro, B, Farina, C, Freeman, M, Gallo, V, Goldman, J E, Goldman, S A, Gotz, M, Gutierrez, A, Haydon, P G, Heiland, D H, Hol, E M, Holt, M G, Iino, M, Kastanenka, K V, Kettenmann, H, Khakh, B S, Koizumi, S, Lee, C J, Liddelow, S A, MacVicar, B A, Magistretti, P, Messing, A, Mishra, A, Molofsky, A V, Murai, K K, Norris, C M, Okada, S, Oliet, S H R, Oliveira, J F, Panatier, A, Parpura, V, Pekna, M, Pekny, M, Pellerin, L, Perea, G, Perez-Nievas, B G, Pfrieger, F W, Poskanzer, K E, Quintana, F J, Ransohoff, R M, Riquelme-Perez, M, Robel, S, Rose, C R, Rothstein, J D, Rouach, N, Rowitch, D H, Semyanov, A, Sirko, S, Sontheimer, H, Swanson, R A, Vitorica, J, Wanner, I-B, Wood, L B, Wu, J, Zheng, B, Zimmer, E R, Zorec, R, Sofroniew, M V & Verkhratsky, A 2021, ' Reactive astrocyte nomenclature, definitions, and future directions ', Nature Neuroscience, vol. 24, pp. 312–325 . https://doi.org/10.1038/s41593-020-00783-4, Nature Neuroscience, Nature Neuroscience, Nature Publishing Group, 2021, 24 (3), pp.312-325. ⟨10.1038/s41593-020-00783-4⟩, Nat Neurosci, Nature Neuroscience, Nature Publishing Group, 2021, 24, pp.312-325. ⟨10.1038/s41593-020-00783-4⟩, Nature neuroscience, vol 24, iss 3, Nature Neuroscience, 2021, 24, pp.312-325. ⟨10.1038/s41593-020-00783-4⟩, Escartin, C, Galea, E, Lakatos, A, O'Callaghan, J P, Petzold, C C, Serrano-Pozo, A, Steinhauser, C, Volterra, A, Carmignoto, G, Agarwal, A, Allen, N J, Araque, A, Barbeito, L, Barzilai, A, Bergles, D E, Bonvento, G, Butt, A M, Chen, W-T, Cohen-Salmon, M, Cunningham, C, Deneen, B, De Strooper, B, Diaz-Castro, B, Farina, C, Freeman, M, Gallo, V, Goldman, J E, Goldman, S A, Gotz, M, Gutierrez, A, Haydon, P G, Heiland, D H, Hol, E M, Holt, M G, Iino, M, Kastanenka, K V, Kettenmann, H, Khakh, B S, Koizumi, S, Lee, C J, Liddelow, S A, MacVicar, B A, Magistretti, P, Messing, A, Mishra, A, Molofsky, A V, Murai, K, Norris, C M, Okada, S, Oliet, S HR, Oliveira, J F, Panatier, A, Parpura, V, Pekna, M, Pekny, M, Pellerin, L, Perea, G, Perez-Nievas, B G, Pfrieger, F W, Poskanazer, K E, Quintana, F J, Ransohoff, R M, Riquelme-Perez, M, Robel, S, Rose, C R, Rothstein, J, Rouach, N, Rowitch, D H, Semyanov, A, Sirko, S, Sontheimer, H, Swanson, R A, Vitorica, J, Wanner, I-B, Wood, L B, Wu, J, Zheng, B, Zimmer, E R, Zorec, R, Sofroniew, M V & Verkhratsky, A 2021, ' Reactive astrocyte nomenclature, definitions, and future directions ', Nature Neuroscience . https://doi.org/10.1038/s41593-020-00783-4
- Publication Year :
- 2021
- Publisher :
- Nature America, 2021.
-
Abstract
- Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, uncertainties and controversies remain regarding the contribution of reactive astrocytes to CNS diseases, repair, and aging. It is also unclear whether fixed categories of reactive astrocytes exist and, if so, how to identify them. We point out the shortcomings of binary divisions of reactive astrocytes into good-vs-bad, neurotoxic-vs-neuroprotective or A1-vs-A2. We advocate, instead, that research on reactive astrocytes include assessment of multiple molecular and functional parameters—preferably in vivo—plus multivariate statistics and determination of impact on pathological hallmarks in relevant models. These guidelines may spur the discovery of astrocyte-based biomarkers as well as astrocyte-targeting therapies that abrogate detrimental actions of reactive astrocytes, potentiate their neuro- and glioprotective actions, and restore or augment their homeostatic, modulatory, and defensive functions.<br />Funding: CNRS, CEA, ANR, and France Alzheimer to CE.; MCINN (PID2019-107633RB-I00) and Generalitat de Catalunya (2017-SGR547, Grup de demències Sant Pau) to E.G. US Centers for Disease Control and Prevention to J. P.O. Alzheimer’s Association (AACF-17-524184) and NIH-NIA (K08AG064039) to A.S.-P. DFG (SPP1757, STE 552/5, STE 552/4), EU (H2020-MSCA-ITN project 722053 EU-GliaPhD) and BMBF (16GW0182 CONNEXIN) to C.S. Swiss National Science Foundation grant 31003A 173124/1; SNSF NCCR ‘Transcure’ (51NF40-160620); Synapsis Foundation Heidi Seiler-Stiftung 2018-PI01 to A.Volterra. NIH-NINDS (NS084030), Dr. Miriam and Sheldon G. Adelson Medical Foundation and Wings for Life to M.V.S. The authors thank T. Yohannan of Alpha Language Services, Barcelona, for expert copy editing.
- Subjects :
- 0301 basic medicine
Aging
[SDV]Life Sciences [q-bio]
Disease
pathology [Spinal Cord]
Article
03 medical and health sciences
0302 clinical medicine
pathology [Aging]
Response to injury
pathology [Brain]
medicine
Psychology
Animals
Humans
ddc:610
Reactive Astrocyte
ComputingMilieux_MISCELLANEOUS
Spinal Cord Injuries
pathology [Astrocytes]
Brain Diseases
Neurology & Neurosurgery
Extramural
business.industry
General Neuroscience
pathology [Brain Injuries]
Neurosciences
pathology [Brain Diseases]
Brain
3. Good health
Brain Disorders
030104 developmental biology
medicine.anatomical_structure
Spinal Cord
Astrocytes
Brain Injuries
Neurological
Cognitive Sciences
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
pathology [Spinal Cord Injuries]
business
Neuroscience
030217 neurology & neurosurgery
Astrocyte
Spinal cord pathology
Subjects
Details
- Language :
- English
- ISSN :
- 10976256 and 15461726
- Database :
- OpenAIRE
- Journal :
- Nature neuroscience 24(3), 312-325 (2021). doi:10.1038/s41593-020-00783-4, Escartin, C, Galea, E, Lakatos, A, O'Callaghan, J P, Petzold, G C, Serrano-Pozo, A, Steinhauser, C, Volterra, A, Carmignoto, G, Agarwal, A, Allen, N J, Araque, A, Barbeito, L, Barzilai, A, Bergles, D E, Bonvento, G, Butt, A M, Chen, W-T, Cohen-Salmon, M, Cunningham, C, Deneen, B, De Strooper, B, Diaz-Castro, B, Farina, C, Freeman, M, Gallo, V, Goldman, J E, Goldman, S A, Gotz, M, Gutierrez, A, Haydon, P G, Heiland, D H, Hol, E M, Holt, M G, Iino, M, Kastanenka, K V, Kettenmann, H, Khakh, B S, Koizumi, S, Lee, C J, Liddelow, S A, MacVicar, B A, Magistretti, P, Messing, A, Mishra, A, Molofsky, A V, Murai, K K, Norris, C M, Okada, S, Oliet, S H R, Oliveira, J F, Panatier, A, Parpura, V, Pekna, M, Pekny, M, Pellerin, L, Perea, G, Perez-Nievas, B G, Pfrieger, F W, Poskanzer, K E, Quintana, F J, Ransohoff, R M, Riquelme-Perez, M, Robel, S, Rose, C R, Rothstein, J D, Rouach, N, Rowitch, D H, Semyanov, A, Sirko, S, Sontheimer, H, Swanson, R A, Vitorica, J, Wanner, I-B, Wood, L B, Wu, J, Zheng, B, Zimmer, E R, Zorec, R, Sofroniew, M V & Verkhratsky, A 2021, ' Reactive astrocyte nomenclature, definitions, and future directions ', Nature Neuroscience, vol. 24, pp. 312–325 . https://doi.org/10.1038/s41593-020-00783-4, Nature Neuroscience, Nature Neuroscience, Nature Publishing Group, 2021, 24 (3), pp.312-325. ⟨10.1038/s41593-020-00783-4⟩, Nat Neurosci, Nature Neuroscience, Nature Publishing Group, 2021, 24, pp.312-325. ⟨10.1038/s41593-020-00783-4⟩, Nature neuroscience, vol 24, iss 3, Nature Neuroscience, 2021, 24, pp.312-325. ⟨10.1038/s41593-020-00783-4⟩, Escartin, C, Galea, E, Lakatos, A, O'Callaghan, J P, Petzold, C C, Serrano-Pozo, A, Steinhauser, C, Volterra, A, Carmignoto, G, Agarwal, A, Allen, N J, Araque, A, Barbeito, L, Barzilai, A, Bergles, D E, Bonvento, G, Butt, A M, Chen, W-T, Cohen-Salmon, M, Cunningham, C, Deneen, B, De Strooper, B, Diaz-Castro, B, Farina, C, Freeman, M, Gallo, V, Goldman, J E, Goldman, S A, Gotz, M, Gutierrez, A, Haydon, P G, Heiland, D H, Hol, E M, Holt, M G, Iino, M, Kastanenka, K V, Kettenmann, H, Khakh, B S, Koizumi, S, Lee, C J, Liddelow, S A, MacVicar, B A, Magistretti, P, Messing, A, Mishra, A, Molofsky, A V, Murai, K, Norris, C M, Okada, S, Oliet, S HR, Oliveira, J F, Panatier, A, Parpura, V, Pekna, M, Pekny, M, Pellerin, L, Perea, G, Perez-Nievas, B G, Pfrieger, F W, Poskanazer, K E, Quintana, F J, Ransohoff, R M, Riquelme-Perez, M, Robel, S, Rose, C R, Rothstein, J, Rouach, N, Rowitch, D H, Semyanov, A, Sirko, S, Sontheimer, H, Swanson, R A, Vitorica, J, Wanner, I-B, Wood, L B, Wu, J, Zheng, B, Zimmer, E R, Zorec, R, Sofroniew, M V & Verkhratsky, A 2021, ' Reactive astrocyte nomenclature, definitions, and future directions ', Nature Neuroscience . https://doi.org/10.1038/s41593-020-00783-4
- Accession number :
- edsair.doi.dedup.....c94bde53ce6b6eff445e92e9ff71c773
- Full Text :
- https://doi.org/10.1038/s41593-020-00783-4