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Novel 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase
- Source :
- Bioorganic & Medicinal Chemistry Letters. 17:974-977
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- A novel class of 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase is described. This report discusses the SAR of 4-(2-hydroxy-2-phenylethylamino)-substituted pyridones with improved IGF-1R potency.
- Subjects :
- Models, Molecular
Pyridones
medicine.medical_treatment
Clinical Biochemistry
Pharmaceutical Science
Biochemistry
Cell Line
Mice
Structure-Activity Relationship
Insulin-like growth factor
Growth factor receptor
Drug Discovery
medicine
Animals
Structure–activity relationship
Insulin-Like Growth Factor I
Molecular Biology
Cell Proliferation
chemistry.chemical_classification
biology
Kinase
Growth factor
Phosphotransferases
Organic Chemistry
Enzyme
chemistry
Enzyme inhibitor
biology.protein
Molecular Medicine
Benzimidazoles
Indicators and Reagents
Signal transduction
Baculoviridae
Thymidine
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....c951ab3913e0e3f58e4cf105cfa4a1d4
- Full Text :
- https://doi.org/10.1016/j.bmcl.2006.11.041