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PRP Treatment Efficacy for Tendinopathy: A Review of Basic Science Studies
- Source :
- BioMed Research International, Vol 2016 (2016), BioMed Research International
- Publication Year :
- 2016
- Publisher :
- Hindawi Limited, 2016.
-
Abstract
- Platelet-Rich Plasma (PRP) has been widely used in orthopaedic surgery and sport medicine to treat tendon injuries. However, the efficacy of PRP treatment for tendinopathy is controversial. This paper focuses on reviewing the basic science studies on PRP performed under well-controlled conditions. Bothin vitroandin vivostudies describe PRP’s anabolic and anti-inflammatory effects on tendons. While some clinical trials support these findings, others refute them. In this review, we discuss the effectiveness of PRP to treat tendon injuries with evidence presented in basic science studies and the potential reasons for the controversial results in clinical trials. Finally, we comment on the approaches that may be required to improve the efficacy of PRP treatment for tendinopathy.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Basic science
animal diseases
lcsh:Medicine
Review Article
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Humans
Medicine
Intensive care medicine
Inflammation
030222 orthopedics
General Immunology and Microbiology
Platelet-Rich Plasma
business.industry
lcsh:R
General Medicine
medicine.disease
Treatment efficacy
nervous system diseases
3. Good health
Clinical trial
030104 developmental biology
Platelet-rich plasma
Tendinopathy
Orthopedic surgery
Physical therapy
business
Subjects
Details
- ISSN :
- 23146141 and 23146133
- Volume :
- 2016
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....c96055576b9d76c30605686138dff4da