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SAPHO Syndrome: Current Developments and Approaches to Clinical Treatment
- Source :
- Current rheumatology reports. 18(6)
- Publication Year :
- 2016
-
Abstract
- SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, and osteitis) is a rare autoimmune disease which, due to its clinical presentation and symptoms, is often misdiagnosed and unrecognized. Its main features are prominent inflammatory cutaneous and articular manifestations. Treatments with immunosuppressive drugs have been used for the management of SAPHO with variable results. To date, the use of anti-TNF-α agents has proved to be an effective alternative to conventional treatment for unresponsive or refractory SAPHO cases. TNF-α is a pro-inflammatory cytokine and pivotal regulator of other cytokines, including IL-1 β, IL-6, and IL-8, involved in inflammation, acute-phase response induction, and chemotaxis. IL-1 inhibition strategies with anakinra have shown efficacy as first and second lines of treatment. In this review, we will describe the main characteristics of biological drugs currently used for SAPHO syndrome. We also describe some of the promising therapeutic effects of ustekinumab, an antibody against the p40 subunit of IL-12 and IL-23, after failure of multiple drugs including anti-TNF-α and anakinra. We discuss the use and impact of the new anti-IL-1 antagonists involved in the IL-17 blockade, in particular for the most difficult-to-treat SAPHO cases.
- Subjects :
- SAPHO syndrome
Acquired Hyperostosis Syndrome
Canakinumab
TNF
Biologicals
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Rheumatology
Synovitis
Ustekinumab
medicine
Adalimumab
Humans
TH17
Cytokine
Osteitis
030203 arthritis & rheumatology
Inflammation
Anakinra
Biological Products
business.industry
Tumor Necrosis Factor-alpha
Autoinflammatory
CRMO
medicine.disease
Pustulosis
Interleukin-1β
Arthritis & Rheumatology
Interleukin 1 Receptor Antagonist Protein
Immunology
medicine.symptom
business
medicine.drug
Interleukin-1
Subjects
Details
- ISSN :
- 15346307
- Volume :
- 18
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Current rheumatology reports
- Accession number :
- edsair.doi.dedup.....c98134da4e428c52d714bc34f76827f5