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Stimulation of Glucose Transport in Cultures of Density-Inhibited Chick Embryo Cells
- Source :
- Proceedings of the National Academy of Sciences. 68:3154-3157
- Publication Year :
- 1971
- Publisher :
- Proceedings of the National Academy of Sciences, 1971.
-
Abstract
- The rate of glucose transport in sparse, rapidly growing chick-embryo fibroblasts is much greater than that in density-inhibited cells. The addition of fresh chicken serum or trypsin to the medium of density-inhibited cells causes a large increase in the rate of glucose transport that is detectable 15 min after addition. The increase in glucose transport precedes the increase in DNA synthesis by 5-6 hr. Only small changes in rates of transport are seen with nucleosides or a nonmetabolizable amino acid. The increase in glucose transport requires protein synthesis but not RNA or DNA synthesis.
- Subjects :
- Aminoisobutyric Acids
Stimulation
Chick Embryo
Growth
Biology
Cycloheximide
Tritium
chemistry.chemical_compound
Leucine
medicine
Protein biosynthesis
Animals
Trypsin
Uridine
Biological Sciences: Cell Biology
Cells, Cultured
Hexoses
chemistry.chemical_classification
Multidisciplinary
DNA synthesis
Immune Sera
Glucose transporter
Biological Transport
Fibroblasts
Amino acid
Glucose
chemistry
Biochemistry
Protein Biosynthesis
Dactinomycin
Chickens
Thymidine
medicine.drug
Subjects
Details
- ISSN :
- 10916490 and 00278424
- Volume :
- 68
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences
- Accession number :
- edsair.doi.dedup.....c98eb199e00da09cc27284d310e1b408