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Biological markers of fertility (inhibin-B) in HIV-infected men: influence of HIV infection and antiretroviral therapy
- Source :
- HIV MEDICINE, r-FISABIO. Repositorio Institucional de Producción Científica, instname, r-FISABIO: Repositorio Institucional de Producción Científica, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- ObjectivesInhibin B (IB) levels and the IB: follicle-stimulating hormone (FSH) ratio (IFR), biomarkers of global Sertoli cell function, show a strong relationship with male fertility. The aim of the study was to examine the prevalence of impaired fertility potential in HIV-infected men and the influence of antiretroviral therapy (ART) on fertility biomarkers. MethodsA cross-sectional study with sequential sampling was carried out. A total of 169 clinically stable patients in a cohort of HIV-infected men undergoing regular ambulatory assessment in a tertiary hospital were included. The mean [ standard deviation (SD)] age of the patients was 42.6 8.1 years, all were clinically stable, 61.5% had disease classified as Centers for Disease Control and Prevention (CDC) stage A, and were na?ve to ART or had not had any changes to ART for 6 months (91.1%). Morning baseline IB and FSH concentrations were measured using an enzyme-linked immunosorbent assay (ELISA) and an electrochemiluminescent immunoassay (ECLIA), respectively. A multivariate logistic regression model was used to identify factors associated with impaired fertility, defined as IB < 119 pg/mL or IFR < 23.5. ResultsThe mean (+/- SD) IB level was 250 +/- 103 pg/mL, the median [interquartile range (IQR)] FSH concentration was 5.1 (3.3-7.8) UI/L and the median (IQR) IFR was 46.1 (26.3-83.7). The prevalence of impaired fertility was 21.9% [95% confidence interval (CI) 16.3-20.7%]. Negative correlations of body mass index and waist: hip ratio with FSH and IB levels were observed (P < 0.01), while a sedentary lifestyle and previous nevirapine exposure were associated with a decreased risk of IB levels 25th percentile in multivariate analysis. Only older age, as a risk factor, and sedentary lifestyle, with a protective effect, were independently associated with impaired fertility in multivariate analysis. ConclusionsGlobal testicular Sertoli cell function and fertility potential, assessed indirectly through serum IB levels and IB: FSH ratio, appear to be well maintained in HIV-infected men and not damaged by ART.
- Subjects :
- Adult
Male
antiretroviral treatment
medicine.medical_specialty
Cross-sectional study
media_common.quotation_subject
HIV Infections
030209 endocrinology & metabolism
Fertility
Gastroenterology
03 medical and health sciences
0302 clinical medicine
inhibin-B
Interquartile range
Internal medicine
medicine
Humans
Inhibins
Pharmacology (medical)
Risk factor
Sedentary lifestyle
media_common
fertility
Gynecology
Sertoli cell
030219 obstetrics & reproductive medicine
business.industry
Health Policy
HIV
Middle Aged
Confidence interval
Cross-Sectional Studies
Infectious Diseases
Anti-Retroviral Agents
Cohort
business
Body mass index
Biomarkers
Subjects
Details
- ISSN :
- 14642662
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- HIV Medicine
- Accession number :
- edsair.doi.dedup.....c990de1fb672eef309918ed22b025a81