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Surveillance of omadacycline activity tested against clinical isolates from the USA: report from the SENTRY Antimicrobial Surveillance Program, 2019
- Source :
- Journal of Global Antimicrobial Resistance, Vol 27, Iss, Pp 337-351 (2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Objectives: Omadacycline was tested against 7000 bacterial isolates collected prospectively from medical centres in the USA during 2019. Methods: Antimicrobial susceptibility testing was performed according to Clinical and Laboratory Standards Institute (CLSI) guidelines. Results: Omadacycline was active against: Staphylococcus aureus (MIC50/90, 0.12/0.25 mg/L; 98.3% susceptible), including methicillin-resistant S. aureus (MRSA); Enterococcus faecalis (MIC50/90, 0.06/0.25 mg/L; 100.0% susceptible), including vancomycin-resistant enterococci (VRE); Streptococcus pneumoniae (MIC50/90, 0.06/0.06 mg/L; 99.8% susceptible); viridans group streptococci, including Streptococcus anginosus group (MIC50/90, 0.03/0.06 mg/L; 100.0% susceptible); β-haemolytic streptococci, including Streptococcus pyogenes (MIC50/90, 0.06/0.12 mg/L; 99.2% susceptible); Enterobacterales (MIC50/90, 1/8 mg/L; 86.9% inhibited at ≤4 mg/L), including Escherichia coli (MIC50/90, 0.5/2 mg/L; 99.6% inhibited at ≤4 mg/L); Enterobacter cloacae (MIC50/90, 2/4 mg/L; 98.5% susceptible); Klebsiella pneumoniae (MIC50/90, 1/4 mg/L; 93.2% susceptible); Acinetobacter baumannii (MIC50/90, 0.5/4 mg/L; 90.8% inhibited at ≤4 mg/L); Haemophilus influenzae (MIC50/90, 0.5/1 mg/L; 100.0% susceptible); and Moraxella catarrhalis (MIC50/90, ≤0.12/0.25 mg/L). Conclusion: The 2019 in vitro activity of omadacycline against key Gram-positive and Gram-negative pathogens has not changed compared with the prior 3 years of surveillance in the SENTRY Antimicrobial Surveillance Program. Omadacycline merits further study in serious infections where resistant pathogens may be encountered.
- Subjects :
- Microbiology (medical)
Methicillin-Resistant Staphylococcus aureus
Klebsiella pneumoniae
Omadacycline
CABP
Immunology
Microbial Sensitivity Tests
MRSA
medicine.disease_cause
Microbiology
Enterococcus faecalis
Haemophilus influenzae
Moraxella catarrhalis
Streptococcus pneumoniae
Immunology and Allergy
Medicine
Surveillance
biology
business.industry
ABSSSI
Antimicrobial
biology.organism_classification
QR1-502
Acinetobacter baumannii
Anti-Bacterial Agents
Staphylococcus aureus
Tetracyclines
business
Subjects
Details
- Language :
- English
- ISSN :
- 22137165
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Journal of Global Antimicrobial Resistance
- Accession number :
- edsair.doi.dedup.....c991d47b45484012d611ae7b33567e50