Back to Search Start Over

Smart, Biomimetic Periosteum Created from the Cerium(III, IV) Oxide-Mineralized Eggshell Membrane

Authors :
Qian-Qian Wan
Kai Jiao
Yu-Xuan Ma
Bo Gao
Zhao Mu
Yi-Rong Wang
Yan-Hao Wang
Lian Duan
Ke-Hui Xu
Jun-Ting Gu
Jian-Fei Yan
Jing Li
Min-Juan Shen
Franklin R. Tay
Li-Na Niu
Source :
ACS Applied Materials & Interfaces. 14:14103-14119
Publication Year :
2022
Publisher :
American Chemical Society (ACS), 2022.

Abstract

The periosteum orchestrates the microenvironment of bone regeneration, including facilitating local neuro-vascularization and regulating immune responses. To mimic the role of natural periosteum for bone repair enhancement, we adopted the principle of biomimetic mineralization to delicately inlay amorphous cerium oxide within eggshell membranes (ESMs) for the first time. Cerium from cerium oxide possesses unique ability to switch its oxidation state from cerium III to cerium IV and vice versa, which provides itself promising potential for biomedical applications. ESMs are mineralized with cerium(III, IV) oxide and examined for their biocompatibility. Apart from serving as physical barriers, periosteum-like cerium(III, IV) oxide-mineralized ESMs are biocompatible and can actively regulate immune responses and facilitate local neuro-vascularization along with early-stage bone regeneration in a murine cranial defect model. During the healing process, cerium-inlayed biomimetic periosteum can boost early osteoclastic differentiation of macrophage lineage cells, which may be the dominant mediator of the local repair microenvironment. The present work provides novel insights into expanding the definition and function of a biomimetic periosteum to boost early-stage bone repair and optimize long-term repair with robust neuro-vascularization. This new treatment strategy which employs multifunctional bone-and-periosteum-mimicking systems creates a highly concerted microenvironment to expedite bone regeneration.

Details

ISSN :
19448252 and 19448244
Volume :
14
Database :
OpenAIRE
Journal :
ACS Applied Materials & Interfaces
Accession number :
edsair.doi.dedup.....c9ae272d58ade735b2c1d82173f27ca2
Full Text :
https://doi.org/10.1021/acsami.2c02079